Novel targets of Akt, p21Cip1/WAF1, and MDM2

Binhua P. Zhou, Mien Chie Hung

Research output: Contribution to journalArticlepeer-review

89 Scopus citations

Abstract

The phosphatidylinositol-3-OH kinase (PI-3K)/Akt signaling pathway plays a critical role In tumorigenesis. This pathway is activated by the amplification or overexpression of HER2/neu, which occurs In 30% of human breast and ovarian cancers. The recent identification of a number of Akt substrates suggests that Akt can enhance cell proliferation and inhibit apoptosis. In this review we will discuss the theme of action of Akt in regulating the cellular localization of its substrates to control proliferation and apoptosis in light of two new identified Akt substrates, p21Cip1/WAF1 and MDM2.

Original languageEnglish
Pages (from-to)62-70
Number of pages9
JournalSeminars in Oncology
Volume29
Issue number3 SUPPL. 11
DOIs
StatePublished - 2002

ASJC Scopus subject areas

  • Hematology
  • Oncology

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