TY - JOUR
T1 - Novel targets of Akt, p21Cip1/WAF1, and MDM2
AU - Zhou, Binhua P.
AU - Hung, Mien Chie
PY - 2002
Y1 - 2002
N2 - The phosphatidylinositol-3-OH kinase (PI-3K)/Akt signaling pathway plays a critical role In tumorigenesis. This pathway is activated by the amplification or overexpression of HER2/neu, which occurs In 30% of human breast and ovarian cancers. The recent identification of a number of Akt substrates suggests that Akt can enhance cell proliferation and inhibit apoptosis. In this review we will discuss the theme of action of Akt in regulating the cellular localization of its substrates to control proliferation and apoptosis in light of two new identified Akt substrates, p21Cip1/WAF1 and MDM2.
AB - The phosphatidylinositol-3-OH kinase (PI-3K)/Akt signaling pathway plays a critical role In tumorigenesis. This pathway is activated by the amplification or overexpression of HER2/neu, which occurs In 30% of human breast and ovarian cancers. The recent identification of a number of Akt substrates suggests that Akt can enhance cell proliferation and inhibit apoptosis. In this review we will discuss the theme of action of Akt in regulating the cellular localization of its substrates to control proliferation and apoptosis in light of two new identified Akt substrates, p21Cip1/WAF1 and MDM2.
UR - http://www.scopus.com/inward/record.url?scp=0036312303&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036312303&partnerID=8YFLogxK
U2 - 10.1016/s0093-7754(02)70128-0
DO - 10.1016/s0093-7754(02)70128-0
M3 - Article
C2 - 12138399
AN - SCOPUS:0036312303
SN - 0093-7754
VL - 29
SP - 62
EP - 70
JO - Seminars in Oncology
JF - Seminars in Oncology
IS - 3 SUPPL. 11
ER -
