Novel targets of Akt, p21Cip1/WAF1, and MDM2

Binhua P. Zhou; Mien Chie Hung

doi:10.1016/s0093-7754(02)70128-0

Novel targets of Akt, p21^Cip1/WAF1, and MDM2

Binhua P. Zhou
, Mien Chie Hung

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

The phosphatidylinositol-3-OH kinase (PI-3K)/Akt signaling pathway plays a critical role In tumorigenesis. This pathway is activated by the amplification or overexpression of HER2/neu, which occurs In 30% of human breast and ovarian cancers. The recent identification of a number of Akt substrates suggests that Akt can enhance cell proliferation and inhibit apoptosis. In this review we will discuss the theme of action of Akt in regulating the cellular localization of its substrates to control proliferation and apoptosis in light of two new identified Akt substrates, p21^Cip1/WAF1 and MDM2.

Original language	English
Pages (from-to)	62-70
Number of pages	9
Journal	Seminars in Oncology
Volume	29
Issue number	3 SUPPL. 11
DOIs	https://doi.org/10.1016/s0093-7754(02)70128-0
State	Published - 2002

Funding

Funders	Funder number
National Childhood Cancer Registry – National Cancer Institute	P50CA083639

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Hematology
Oncology

Access to Document

10.1016/s0093-7754(02)70128-0

Cite this

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title = "Novel targets of Akt, p21Cip1/WAF1, and MDM2",

abstract = "The phosphatidylinositol-3-OH kinase (PI-3K)/Akt signaling pathway plays a critical role In tumorigenesis. This pathway is activated by the amplification or overexpression of HER2/neu, which occurs In 30\% of human breast and ovarian cancers. The recent identification of a number of Akt substrates suggests that Akt can enhance cell proliferation and inhibit apoptosis. In this review we will discuss the theme of action of Akt in regulating the cellular localization of its substrates to control proliferation and apoptosis in light of two new identified Akt substrates, p21Cip1/WAF1 and MDM2.",

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AB - The phosphatidylinositol-3-OH kinase (PI-3K)/Akt signaling pathway plays a critical role In tumorigenesis. This pathway is activated by the amplification or overexpression of HER2/neu, which occurs In 30% of human breast and ovarian cancers. The recent identification of a number of Akt substrates suggests that Akt can enhance cell proliferation and inhibit apoptosis. In this review we will discuss the theme of action of Akt in regulating the cellular localization of its substrates to control proliferation and apoptosis in light of two new identified Akt substrates, p21Cip1/WAF1 and MDM2.

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