Novel zafirlukast derivatives exhibit selective antibacterial activity against: Porphyromonas gingivalis

Nishad Thamban Chandrika, Marina Y. Fosso, Yelena Alimova, Abigail May, Octavio A. Gonzalez, Sylvie Garneau-Tsodikova

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Periodontal disease is an oral chronic immune-inflammatory disease highly prevalent worldwide that is initiated by specific oral bacterial species leading to local and systemic effects. The development of new preventive/therapeutic strategies to specifically target oral periodontopathogens without perturbing oral microbiome species normally colonizing the oral cavity is needed. The fast and affordable strategy of repositioning of already FDA-approved drugs can be an answer to the development of novel treatments against periodontal pathogens such as Porphyromonas gingivalis. Herein, we report the synthesis and antibacterial activity of novel zafirlukast derivatives, their bactericidal effect, and their cytotoxicity against oral epithelial cell lines. Many of these derivatives exhibited superior antibacterial activity against P. gingivalis compared to the parent drug zafirlukast. The most promising compounds were found to be selective against P. gingivalis and they were bactericidal in their activity. Finally, we demonstrated that these potent derivatives of zafirlukast provided a better safety profile against oral epithelial cells compared to zafirlukast.

Original languageEnglish
Pages (from-to)926-933
Number of pages8
JournalMedChemComm
Volume10
Issue number6
DOIs
StatePublished - 2019

Bibliographical note

Publisher Copyright:
© 2019 The Royal Society of Chemistry.

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Novel zafirlukast derivatives exhibit selective antibacterial activity against: Porphyromonas gingivalis'. Together they form a unique fingerprint.

Cite this