Abstract
Chromosome Region Maintenance 1 (CRM1), also known as Exportin 1 (XPO1), is a protein that is critical for transport of proteins and RNA to the cytoplasm through the nuclear pore complex. CRM1 inhibition with small molecule inhibitors is currently being studied in many cancers, including leukemias, solid organ malignancies and brain tumors. We review the structure of CRM1, its role in nuclear export, the current availability of CRM1 inhibitors, and the role of CRM1 in a number of distinct cellular processes. A deeper understanding of how CRM1 functions in nuclear export as well as other cellular processes may allow for the development of additional novel CRM1 inhibitors.
| Original language | English |
|---|---|
| Article number | 1427497 |
| Journal | Oncology Reviews |
| Volume | 18 |
| DOIs | |
| State | Published - 2024 |
Bibliographical note
Publisher Copyright:Copyright © 2024 Aumann, Kazi, Harrington and Wechsler.
Funding
The authors declare that financial support was received for the research, authorship, and/or publication of this article. WA receives support from Swim Across America, Hyundai Hope on Wheels, and the St. Baldrick’s Foundation.
| Funders | Funder number |
|---|---|
| GIST Cancer Research Fund and Swim Across America | |
| Hyundai Hope on Wheels | |
| St. Baldrick's Foundation |
Keywords
- CRM1
- XPO1
- cancer
- leptomycin B
- nuclear export
ASJC Scopus subject areas
- Oncology
- Cancer Research
