Abstract
High levels of oxidant stress in the form of reactive oxidant species are prevalent in the circulation and tissues in various types of cardiovascular disease including heart failure, hypertension, peripheral arterial disease, and stroke. Here we review the role of nuclear factor erythroid 2-related factor 2 (Nrf2), an important and widespread antioxidant and anti-inflammatory transcription factor that may contribute to the pathogenesis and maintenance of cardiovascular diseases. We review studies showing that downregulation of Nrf2 exacerbates heart failure, hypertension, and autonomic function. Finally, we discuss the potential for using Nrf2 modulation as a therapeutic strategy for cardiovascular diseases and autonomic dysfunction.
| Original language | English |
|---|---|
| Pages (from-to) | 288-301 |
| Number of pages | 14 |
| Journal | Physiology |
| Volume | 39 |
| Issue number | 5 |
| DOIs | |
| State | Published - Sep 2024 |
Bibliographical note
Publisher Copyright:© 2024 Int. Union Physiol. Sci./Am. Physiol. Soc.
Funding
Some of the studies cited above were supported by National Heart, Lung, and Blood Institute Grants P01 HL-62222 and R01 HL-153176. I.H.Z. and N.D. were partially supported by the Theodore F. Hubbard Family Foundation.
| Funders | Funder number |
|---|---|
| Theodore F. Hubbard Family Foundation | |
| National Heart, Lung, and Blood Institute (NHLBI) | R01 HL-153176, P01 HL-62222 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Nrf2
- antioxidant proteins
- heart failure
- hypertension
- oxidative stress
ASJC Scopus subject areas
- Physiology
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