Nuclear export signal of PRRSV NSP1α is necessary for type I IFN inhibition

Zhi Chen, Shaoning Liu, Wenbo Sun, Lei Chen, Dongwan Yoo, Feng Li, Sufang Ren, Lihui Guo, Xiaoyan Cong, Jun Li, Shun Zhou, Jiaqiang Wu, Yijun Du, Jinbao Wang

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


The nonstructural protein 1α (NSP1α) of porcine reproductive and respiratory syndrome virus (PRRSV) is a nucleo-cytoplasmic protein that suppresses the production of type I interferon (IFN). In this study, we investigated the relationship between the subcellular distribution of NSP1α and its inhibition of type I IFN. NSP1α was found to contain the classical nuclear export signal (NES) and NSP1α nuclear export was CRM-1-mediated. NSP1α was shuttling between the nucleus and cytoplasm. We also showed that the nuclear export of NSP1α was necessary for its ability for type I IFN inhibition. NSP1α was also found to interact with CBP, which implies a possible mechanism of CBP degradation by NSP1α. Taken together, our results describe a novel mechanism of PRRSV NSP1α for type I IFN inhibition and suppression of the host innate antiviral response.

Original languageEnglish
Pages (from-to)278-287
Number of pages10
StatePublished - Dec 1 2016

Bibliographical note

Publisher Copyright:
© 2016


  • NSP1α
  • Nuclear export signal (NES)
  • Type I IFN

ASJC Scopus subject areas

  • Virology


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