Nuclear Glycogenolysis Modulates Histone Acetylation in Human Non-Small Cell Lung Cancers

Ramon C. Sun; Vikas V. Dukhande; Zhengqiu Zhou; Lyndsay E.A. Young; Shane Emanuelle; Christine Fillmore Brainson; Matthew S. Gentry

doi:10.1016/j.cmet.2019.08.014

Nuclear Glycogenolysis Modulates Histone Acetylation in Human Non-Small Cell Lung Cancers

Ramon C. Sun, Vikas V. Dukhande, Zhengqiu Zhou, Lyndsay E.A. Young, Shane Emanuelle, Christine Fillmore Brainson, Matthew S. Gentry

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

Nuclear glycogen accumulation has been reported in multiple cancers. Sun et al. show that glycogen is de novo synthesized in the nucleus, and nuclear glycogenolysis provides a carbon pool for histone acetylation. Non-small cell lung cancers suppress nuclear glycogenolysis by down-regulating a key E3 ubiquitin ligase to drive cancer progression.

Original language	English
Pages (from-to)	903-916.e7
Journal	Cell Metabolism
Volume	30
Issue number	5
DOIs	https://doi.org/10.1016/j.cmet.2019.08.014
State	Published - Nov 5 2019

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Inc.

Keywords

E3 ubiquitin ligase
EPM2B
Lafora disease
NHLRC1
glycogen
glycogen phosphorylase
histone acetylation
malin
non-small cell lung cancer
nuclear metabolism

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cmet.2019.08.014

Cite this

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title = "Nuclear Glycogenolysis Modulates Histone Acetylation in Human Non-Small Cell Lung Cancers",

abstract = "Nuclear glycogen accumulation has been reported in multiple cancers. Sun et al. show that glycogen is de novo synthesized in the nucleus, and nuclear glycogenolysis provides a carbon pool for histone acetylation. Non-small cell lung cancers suppress nuclear glycogenolysis by down-regulating a key E3 ubiquitin ligase to drive cancer progression.",

keywords = "E3 ubiquitin ligase, EPM2B, Lafora disease, NHLRC1, glycogen, glycogen phosphorylase, histone acetylation, malin, non-small cell lung cancer, nuclear metabolism",

author = "Sun, {Ramon C.} and Dukhande, {Vikas V.} and Zhengqiu Zhou and Young, {Lyndsay E.A.} and Shane Emanuelle and Brainson, {Christine Fillmore} and Gentry, {Matthew S.}",

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year = "2019",

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day = "5",

doi = "10.1016/j.cmet.2019.08.014",

language = "English",

volume = "30",

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TY - JOUR

T1 - Nuclear Glycogenolysis Modulates Histone Acetylation in Human Non-Small Cell Lung Cancers

AU - Sun, Ramon C.

AU - Dukhande, Vikas V.

AU - Zhou, Zhengqiu

AU - Young, Lyndsay E.A.

AU - Emanuelle, Shane

AU - Brainson, Christine Fillmore

AU - Gentry, Matthew S.

PY - 2019/11/5

Y1 - 2019/11/5

N2 - Nuclear glycogen accumulation has been reported in multiple cancers. Sun et al. show that glycogen is de novo synthesized in the nucleus, and nuclear glycogenolysis provides a carbon pool for histone acetylation. Non-small cell lung cancers suppress nuclear glycogenolysis by down-regulating a key E3 ubiquitin ligase to drive cancer progression.

AB - Nuclear glycogen accumulation has been reported in multiple cancers. Sun et al. show that glycogen is de novo synthesized in the nucleus, and nuclear glycogenolysis provides a carbon pool for histone acetylation. Non-small cell lung cancers suppress nuclear glycogenolysis by down-regulating a key E3 ubiquitin ligase to drive cancer progression.

KW - E3 ubiquitin ligase

KW - EPM2B

KW - Lafora disease

KW - NHLRC1

KW - glycogen

KW - glycogen phosphorylase

KW - histone acetylation

KW - malin

KW - non-small cell lung cancer

KW - nuclear metabolism

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UR - http://www.scopus.com/inward/citedby.url?scp=85074127670&partnerID=8YFLogxK

U2 - 10.1016/j.cmet.2019.08.014

DO - 10.1016/j.cmet.2019.08.014

M3 - Article

C2 - 31523006

AN - SCOPUS:85074127670

SN - 1550-4131

VL - 30

SP - 903-916.e7

JO - Cell Metabolism

JF - Cell Metabolism

IS - 5

ER -

Nuclear Glycogenolysis Modulates Histone Acetylation in Human Non-Small Cell Lung Cancers

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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