Nucleotide excision repair in the yeast Saccharomyces cerevisiae: its relationship to specialized mitotic recombination and RNA polymerase II basal transcription.

E. C. Friedberg; A. J. Bardwell; L. Bardwell; W. J. Feaver; R. D. Kornberg; J. Q. Svejstrup; A. E. Tomkinson; Z. Wang

doi:10.1098/rstb.1995.0010

Nucleotide excision repair in the yeast Saccharomyces cerevisiae: its relationship to specialized mitotic recombination and RNA polymerase II basal transcription.

E. C. Friedberg, A. J. Bardwell, L. Bardwell, W. J. Feaver, R. D. Kornberg, J. Q. Svejstrup, A. E. Tomkinson, Z. Wang

Toxicology and Cancer Biology

Research output: Contribution to journal › Review article › peer-review

37 Scopus citations

Abstract

Nucleotide excision repair (NER) in eukaryotes is a biochemically complex process involving multiple gene products. The budding yeast Saccharomyces cerevisiae is an informative model for this process. Multiple genes and in some cases gene products that are indispensable for NER have been isolated from this organism. Homologues of many of these yeast genes are structurally and functionally conserved in higher organisms, including humans. The yeast Rad1/Rad10 heterodimeric protein complex is an endonuclease that is believed to participate in damage-specific incision of DNA during NER. This endonuclease is also required for specialized types of recombination. The products of the RAD3, SSL2(RAD25) SSL1 and TFB1 genes have dual roles in NER and in RNA polymerase II-dependent basal transcription.

Original language	English
Pages (from-to)	63-68
Number of pages	6
Journal	Philosophical Transactions of the Royal Society B: Biological Sciences
Volume	347
Issue number	1319
DOIs	https://doi.org/10.1098/rstb.1995.0010
State	Published - Jan 30 1995

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology (all)
Agricultural and Biological Sciences (all)

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Friedberg, E. C., Bardwell, A. J., Bardwell, L., Feaver, W. J., Kornberg, R. D., Svejstrup, J. Q., Tomkinson, A. E., & Wang, Z. (1995). Nucleotide excision repair in the yeast Saccharomyces cerevisiae: its relationship to specialized mitotic recombination and RNA polymerase II basal transcription. Philosophical Transactions of the Royal Society B: Biological Sciences, 347(1319), 63-68. https://doi.org/10.1098/rstb.1995.0010

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abstract = "Nucleotide excision repair (NER) in eukaryotes is a biochemically complex process involving multiple gene products. The budding yeast Saccharomyces cerevisiae is an informative model for this process. Multiple genes and in some cases gene products that are indispensable for NER have been isolated from this organism. Homologues of many of these yeast genes are structurally and functionally conserved in higher organisms, including humans. The yeast Rad1/Rad10 heterodimeric protein complex is an endonuclease that is believed to participate in damage-specific incision of DNA during NER. This endonuclease is also required for specialized types of recombination. The products of the RAD3, SSL2(RAD25) SSL1 and TFB1 genes have dual roles in NER and in RNA polymerase II-dependent basal transcription.",

author = "Friedberg, {E. C.} and Bardwell, {A. J.} and L. Bardwell and Feaver, {W. J.} and Kornberg, {R. D.} and Svejstrup, {J. Q.} and Tomkinson, {A. E.} and Z. Wang",

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Friedberg, EC, Bardwell, AJ, Bardwell, L, Feaver, WJ, Kornberg, RD, Svejstrup, JQ, Tomkinson, AE & Wang, Z 1995, 'Nucleotide excision repair in the yeast Saccharomyces cerevisiae: its relationship to specialized mitotic recombination and RNA polymerase II basal transcription.', Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 347, no. 1319, pp. 63-68. https://doi.org/10.1098/rstb.1995.0010

Nucleotide excision repair in the yeast Saccharomyces cerevisiae: its relationship to specialized mitotic recombination and RNA polymerase II basal transcription. / Friedberg, E. C.; Bardwell, A. J.; Bardwell, L. et al.
In: Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 347, No. 1319, 30.01.1995, p. 63-68.

Research output: Contribution to journal › Review article › peer-review

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AU - Bardwell, A. J.

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AU - Feaver, W. J.

AU - Kornberg, R. D.

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AU - Tomkinson, A. E.

AU - Wang, Z.

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AB - Nucleotide excision repair (NER) in eukaryotes is a biochemically complex process involving multiple gene products. The budding yeast Saccharomyces cerevisiae is an informative model for this process. Multiple genes and in some cases gene products that are indispensable for NER have been isolated from this organism. Homologues of many of these yeast genes are structurally and functionally conserved in higher organisms, including humans. The yeast Rad1/Rad10 heterodimeric protein complex is an endonuclease that is believed to participate in damage-specific incision of DNA during NER. This endonuclease is also required for specialized types of recombination. The products of the RAD3, SSL2(RAD25) SSL1 and TFB1 genes have dual roles in NER and in RNA polymerase II-dependent basal transcription.

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Friedberg EC, Bardwell AJ, Bardwell L, Feaver WJ, Kornberg RD, Svejstrup JQ et al. Nucleotide excision repair in the yeast Saccharomyces cerevisiae: its relationship to specialized mitotic recombination and RNA polymerase II basal transcription. Philosophical Transactions of the Royal Society B: Biological Sciences. 1995 Jan 30;347(1319):63-68. doi: 10.1098/rstb.1995.0010

Nucleotide excision repair in the yeast Saccharomyces cerevisiae: its relationship to specialized mitotic recombination and RNA polymerase II basal transcription.

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