TY - JOUR
T1 - Nucleotide excision repair in the yeast Saccharomyces cerevisiae
T2 - Its relationship to specialized mitotic recombination and RNA polymerase II basal transcription
AU - Friedberg, Errol C.
AU - Bardwell, A. Jane
AU - Bardwell, Lee
AU - Feaver, William J.
AU - Kornberg, Roger D.
AU - Svejstrup, Jesper Q.
AU - Tomkinson, Alan E.
AU - Wang, Zhigang
N1 - Publisher Copyright:
© 1995 Royal Society Publishing. All rights reserved.
PY - 1995/1/1
Y1 - 1995/1/1
N2 - Nucleotide excision repair (ner) in eukaryotes is a biochemically complex process involving multiple gene products. The budding yeast Saccharomyces cerevisiae is an informative model for this process. Multiple genes and in some cases gene products that are indispensable for NER have been isolated from this organism. Homologues of many of these yeast genes are structurally and functionally conserved in higher organisms, including humans. The yeast Radi/Rad 10 heterodimeric protein complex is an endonuclease that is believed to participate in damage-specific incision of DNA during ner. This endonuclease is also required for specialized types of recombination. The products of the RAD3,SSL2(RAD25) SSL1 and TFB1 genes have dual roles in NER and in RNA polymerase II-dependent basal transcription.
AB - Nucleotide excision repair (ner) in eukaryotes is a biochemically complex process involving multiple gene products. The budding yeast Saccharomyces cerevisiae is an informative model for this process. Multiple genes and in some cases gene products that are indispensable for NER have been isolated from this organism. Homologues of many of these yeast genes are structurally and functionally conserved in higher organisms, including humans. The yeast Radi/Rad 10 heterodimeric protein complex is an endonuclease that is believed to participate in damage-specific incision of DNA during ner. This endonuclease is also required for specialized types of recombination. The products of the RAD3,SSL2(RAD25) SSL1 and TFB1 genes have dual roles in NER and in RNA polymerase II-dependent basal transcription.
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U2 - 10.1098/rstb.1995.0010
DO - 10.1098/rstb.1995.0010
M3 - Article
C2 - 7746856
AN - SCOPUS:0029654302
SN - 0962-8436
VL - 347
SP - 63
EP - 68
JO - Philosophical Transactions of the Royal Society B: Biological Sciences
JF - Philosophical Transactions of the Royal Society B: Biological Sciences
IS - 1319
ER -