To understand the mechanisms of angiogenesis, a mathematical model was developed for quantitative analysis of various biological events involved in angiogenesis. The model was focused on twodimensional angiogenesis in the cornea. The model considered diffusion of angiogenic factors, uptake of these factors by endothelial cells, and randomness in the direction and the probability of sprout formation. The mathematical model can be used to evaluate effects of individual factors on angiogenesis, understand mechanisms of interactions among different factors during angiogenesis, and generate experimentally testable hypotheses.
|Journal||Annals of Biomedical Engineering|
|Issue number||SUPPL. 1|
|State||Published - 2000|
|Event||2000 Annual Fall Meeting of the Biomedical Engineering Society - Washington, WA, USA|
Duration: Oct 12 2000 → Oct 14 2000
Bibliographical noteFunding Information:
The study was supported in part by a grant from the Department of Defense (BC980191).
ASJC Scopus subject areas
- Biomedical Engineering