Numerical simulations of angiogenesis in the cornea

Sheng Tong, Fan Yuan

Research output: Contribution to journalConference articlepeer-review


To understand the mechanisms of angiogenesis, a mathematical model was developed for quantitative analysis of various biological events involved in angiogenesis. The model was focused on twodimensional angiogenesis in the cornea. The model considered diffusion of angiogenic factors, uptake of these factors by endothelial cells, and randomness in the direction and the probability of sprout formation. The mathematical model can be used to evaluate effects of individual factors on angiogenesis, understand mechanisms of interactions among different factors during angiogenesis, and generate experimentally testable hypotheses.

Original languageEnglish
Pages (from-to)S-77
JournalAnnals of Biomedical Engineering
Issue numberSUPPL. 1
StatePublished - 2000
Event2000 Annual Fall Meeting of the Biomedical Engineering Society - Washington, WA, USA
Duration: Oct 12 2000Oct 14 2000

Bibliographical note

Funding Information:
The study was supported in part by a grant from the Department of Defense (BC980191).

ASJC Scopus subject areas

  • Biomedical Engineering


Dive into the research topics of 'Numerical simulations of angiogenesis in the cornea'. Together they form a unique fingerprint.

Cite this