Nutrition and inflammation: Role of dietary cholesterol

Alan Chait, Katherine Lewis, Lisa Tannock, Kevin O'Brien, Barbara Retzlaff, Steven Kahn, Robert Knopp, Thomas Wight

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Most HDL particles are anti-atherogenic by virtue of their role in reverse cholesterol transport. However, the presence of apolipoproteins such as apo E and serum amyloid A (SAA) on a subset of HDL particles allows these particles to bind to vascular proteoglycans. This can lead to the retention of these HDL subspecies in the artery wall, their subsequent modification by oxidation and enzyme digestion, and thus their ability to be pro-atherogenic. Because dietary cholesterol can increase circulating SAA levels, it may play a role in atherogenesis by facilitating the retention of SAA-containing HDL by vascular proteoglycans.

Original languageEnglish
Pages (from-to)313-316
Number of pages4
JournalInternational Congress Series
Issue numberC
StatePublished - May 1 2004


  • Atherosclerosis
  • Diet
  • Inflammation
  • Proteoglycans
  • Serum amyloid A

ASJC Scopus subject areas

  • General Medicine


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