TY - JOUR
T1 - Nutrition and inflammation
T2 - Role of dietary cholesterol
AU - Chait, Alan
AU - Lewis, Katherine
AU - Tannock, Lisa
AU - O'Brien, Kevin
AU - Retzlaff, Barbara
AU - Kahn, Steven
AU - Knopp, Robert
AU - Wight, Thomas
PY - 2004/5/1
Y1 - 2004/5/1
N2 - Most HDL particles are anti-atherogenic by virtue of their role in reverse cholesterol transport. However, the presence of apolipoproteins such as apo E and serum amyloid A (SAA) on a subset of HDL particles allows these particles to bind to vascular proteoglycans. This can lead to the retention of these HDL subspecies in the artery wall, their subsequent modification by oxidation and enzyme digestion, and thus their ability to be pro-atherogenic. Because dietary cholesterol can increase circulating SAA levels, it may play a role in atherogenesis by facilitating the retention of SAA-containing HDL by vascular proteoglycans.
AB - Most HDL particles are anti-atherogenic by virtue of their role in reverse cholesterol transport. However, the presence of apolipoproteins such as apo E and serum amyloid A (SAA) on a subset of HDL particles allows these particles to bind to vascular proteoglycans. This can lead to the retention of these HDL subspecies in the artery wall, their subsequent modification by oxidation and enzyme digestion, and thus their ability to be pro-atherogenic. Because dietary cholesterol can increase circulating SAA levels, it may play a role in atherogenesis by facilitating the retention of SAA-containing HDL by vascular proteoglycans.
KW - Atherosclerosis
KW - Diet
KW - Inflammation
KW - Proteoglycans
KW - Serum amyloid A
UR - http://www.scopus.com/inward/record.url?scp=85023156480&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85023156480&partnerID=8YFLogxK
U2 - 10.1016/j.ics.2003.11.019
DO - 10.1016/j.ics.2003.11.019
M3 - Article
AN - SCOPUS:85023156480
SN - 0531-5131
VL - 1262
SP - 313
EP - 316
JO - International Congress Series
JF - International Congress Series
IS - C
ER -