Nutrition, Endothelial Cell Metabolism, and Atherosclerosis

Bernhard Hennig, Michal Toborek, Angelina Alvarado Cader

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


The vascular endothelium that forms an interface between the blood and the surrounding tissues is continuously exposed to both physiologic and pathophysiologic stimuli. These stimuli are often mediated by nutrients that can contribute to the overall function of the endothelial cell in the regulation of vascular tone, coagulation and fibrinolysis, cellular growth and differentiation, and immune and inflammatory responses. Therefore, nutrient-mediated functional changes of the endothelium and the underlying tissues may be significantly involved in the atherosclerotic disease process. There is evidence that individual nutrients or nutrient derivatives may either provoke or prevent metabolic and physiologic perturbations of the vascular endothelium. Preservation of nutrients that exhibit antiatherogenic properties may, therefore, be a critical issue in the preparation and processing of foods. This review focuses on selected nutrients as they affect endothelial cell metabolism and their possible implications in atherosclerosis.

Original languageEnglish
Pages (from-to)253-282
Number of pages30
JournalCritical Reviews in Food Science and Nutrition
Issue number3
StatePublished - Jan 1 1994


  • amino acids
  • endothelial cell integrity
  • fatty acids
  • glucose
  • minerals
  • vitamins

ASJC Scopus subject areas

  • Food Science
  • Industrial and Manufacturing Engineering


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