Nutritional redox homeostasis and cellular stress response: Differential role of homocysteine and acetylcarnitine

Vittorio Calabrese, Riccardo Ientile, Carolin Cornelius, Marina Scalia, Maria T. Cambria, Bernardo Ventimiglia, Giovanni Pennisi, Cesare Mancuso, D. Allan Butterfield

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

5 Scopus citations


In this chapter, we describe the more recent discoveries about the biochemical changes occurring in the central nervous system (CNS), when brain cells are exposed to chronic oxidative insult as well as the key role played by the heat shock response, particularly the heme oxygenase (Hsp32) and Hsp70 pathways. Increasing evidence underscores the high potential of the Hsp system as a target for new neuroprotective strategies, especially those aimed at minimizing deleterious consequences associated with oxidative stress, such as in neurodegenerative disorders and brain aging. We review here the evidence for the emerging role of homocysteine in the pathogenesis of neurodegenerative damage as well as the role of acetylcarnitine in modulating redox-dependent mechanisms leading to upregulation of vitagenes in brain, and hence potentiate brain stress tolerance.

Original languageEnglish
Title of host publicationDietary Modulation of Cell Signaling Pathways
Number of pages22
ISBN (Electronic)9780849381492
StatePublished - Jan 1 2008

Bibliographical note

Publisher Copyright:
© 2009 by Taylor & Francis Group, LLC.

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Medicine


Dive into the research topics of 'Nutritional redox homeostasis and cellular stress response: Differential role of homocysteine and acetylcarnitine'. Together they form a unique fingerprint.

Cite this