Observations on the cellular effects of ethanol and hyperthermia in vivo

R. L. Anderson, R. G. Ahier, J. M. Littleton

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The presence of ethanol in mice not previously exposed to the drug potentiates the damage caused by hyperthermia to the skin of the ear. Similarly, when thermotolerance is induced in the ear by a prior heat treatment, ethanol given before the second heat treatment reduces the amount of thermotolerance that is expressed. Conversely, mice that have developed ethanol tolerance after exposure to ethanol vapor for 7 days display resistance to hyperthermia-induced necrosis. It is possible that there may be similarities in the direct cellular effects of heat and ethanol, and that the development of tolerance to ethanol and hyperthermia may be by a similar mechanism.

Original languageEnglish
Pages (from-to)318-325
Number of pages8
JournalRadiation Research
Volume94
Issue number2
DOIs
StatePublished - 1983

ASJC Scopus subject areas

  • Biophysics
  • Radiation
  • Radiology Nuclear Medicine and imaging

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