Obstetric factors and relative risk of neonatal germinal layer/intraventricular hemorrhage

Henrietta S. Bada, Sheldon B. Korones, Garland D. Anderson, Hubert L. Magill, Seok P. Wong

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


One hundred fifty-five inborn infants with a birth weight <- 1,500 gm were prospectively evaluated for germinal layer/intraventricular hemorrhage. Maternal characteristics, obstetric factors, and neonatal condition in the immediate newborn period were analyzed as possible risk factors for germinal layer/intraventricular hemorrhage. Early germinal layer/intraventricular hemorrhage or hemorrhages identified during the first 24 hours of life were observed in 85 (55%) of these infants. Another 37 (24%) had germinal layer/intraventricular hemorrhage after 24 hours of age (late germinal layer/intraventricular hemorrhage). None of the maternal and obstetric variables, including labor, mode of delivery, and presentation, appeared to increase the risk of germinal layer/intraventricular hemorrhage. The immediate neonatal condition, birth weight, gestational age, and intrauterine growth, all influenced the occurrence of germinal layer/intraventricular hemorrhage, especially early germinal layer/intraventricular hemorrhage. We suggest that future studies to investigate the role of maternal or obstetric factors in the pathogenesis of germinal layer/intraventricular hemorrhage should discriminate early from late germinal layer/intraventricular hemorrhage. Obstetric factors are more likely to influence the early onset of germinal layer/intraventricular hemorrhage; their effect, if any, becomes less discernible later.

Original languageEnglish
Pages (from-to)798-804
Number of pages7
JournalAmerican Journal of Obstetrics and Gynecology
Issue number6
StatePublished - Mar 15 1984

Bibliographical note

Funding Information:
From the Departments of Pediatrics, Obstetrics and Gynecology, and Radiology, The University of Tennessee Center for the Health Sci-ences, and the Department of Mathematical Sciences, Memphis Stale University. Supported in part by the March of Dimes Birth Dejects Foundation Research Grant No. 6-297. ReceivedforpublicationJune 13,1983. Revised September 23, 1983. Accepted October 5, 1983. Reprint requests: Henrietta S. Bada, M.D., Newborn Center, 853 Jefferson, Room 301, Memphis, Tennessee 38163.

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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