Occupational exposures and movement abnormalities among Japanese-American men: The Honolulu-Asia Aging Study

Luenda E. Charles, Cecil M. Burchfiel, Desta Fekedulegn, Michael L. Kashon, G. Webster Ross, Helen Petrovitch, Wayne T. Sanderson

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Objective: The authors analyzed data on 1,049 men aged 71-93 years (excluding those with prevalent Parkinson's disease and stroke) from the Honolulu Heart Program (1965-1968) and the Honolulu-Asia Aging Study (1991-1999) to determine whether occupational exposures to pesticides, solvents, metals, manganese, and mercury during middle age were associated with 14 movement abnormalities 25 years later. Methods: Analyses of variance and multivariate logistic regression were used to assess associations of interest. Results: After adjustment for age, BMI, cognitive functioning, smoking, alcohol drinking, education, and physical activity, there was a positive association between abnormal 'facial expression' and the highest exposure to metals [odds ratio (OR) = 2.62; 95% confidence interval (CI) = 1.35-5.11; trend, p = 0.02], and the highest exposure to mercury (OR = 1.91; 95% CI = 1.04-3.49; trend, p = 0.03). Age was positively associated with all movement abnormalities, and cognitive function, body mass index and physical activity were inversely associated with most movement abnormalities. Conclusion: Higher exposure to any metal, and specifically mercury, was associated with abnormal facial expression.

Original languageEnglish
Pages (from-to)130-139
Number of pages10
Issue number3
StatePublished - Apr 2006


  • Movement abnormalities
  • Neurological signs
  • Normal aging
  • Occupational toxin exposures

ASJC Scopus subject areas

  • Epidemiology
  • Clinical Neurology


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