Occurrence of renal Fanconi syndrome in children on valproic acid therapy

Stephen J. Ryan; Nancy A. Bishof; Robert J. Baumann

doi:10.1016/0896-6974(95)00056-9

Occurrence of renal Fanconi syndrome in children on valproic acid therapy

Stephen J. Ryan, Nancy A. Bishof, Robert J. Baumann

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Two children taking valproic acid (VPA) developed renal Fanconi syndrome, a clinically subtle and potentially dangerous disorder. Discontinuation of VPA was associated with complete recovery of renal tubular function in 1 patient. A study of 100 children taking VPA did not identify another youngster with this complication, suggesting the maximum risk is less than 3%. Children who suffered perinatal anoxia and those taking VPA as opposed to divalproex sodium may be at increased risk. We recommend screening children receiving VPA for this potentially reversible renal tubulopathy.

Original language	English
Pages (from-to)	35-38
Number of pages	4
Journal	Journal of Epilepsy
Volume	9
Issue number	1
DOIs	https://doi.org/10.1016/0896-6974(95)00056-9
State	Published - 1996

Keywords

Children
Fanconi syndrome
Renal
Valproic acid

ASJC Scopus subject areas

General Neuroscience
Clinical Neurology

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10.1016/0896-6974(95)00056-9

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title = "Occurrence of renal Fanconi syndrome in children on valproic acid therapy",

abstract = "Two children taking valproic acid (VPA) developed renal Fanconi syndrome, a clinically subtle and potentially dangerous disorder. Discontinuation of VPA was associated with complete recovery of renal tubular function in 1 patient. A study of 100 children taking VPA did not identify another youngster with this complication, suggesting the maximum risk is less than 3%. Children who suffered perinatal anoxia and those taking VPA as opposed to divalproex sodium may be at increased risk. We recommend screening children receiving VPA for this potentially reversible renal tubulopathy.",

keywords = "Children, Fanconi syndrome, Renal, Valproic acid",

author = "Ryan, {Stephen J.} and Bishof, {Nancy A.} and Baumann, {Robert J.}",

year = "1996",

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T1 - Occurrence of renal Fanconi syndrome in children on valproic acid therapy

AU - Ryan, Stephen J.

AU - Bishof, Nancy A.

AU - Baumann, Robert J.

PY - 1996

Y1 - 1996

N2 - Two children taking valproic acid (VPA) developed renal Fanconi syndrome, a clinically subtle and potentially dangerous disorder. Discontinuation of VPA was associated with complete recovery of renal tubular function in 1 patient. A study of 100 children taking VPA did not identify another youngster with this complication, suggesting the maximum risk is less than 3%. Children who suffered perinatal anoxia and those taking VPA as opposed to divalproex sodium may be at increased risk. We recommend screening children receiving VPA for this potentially reversible renal tubulopathy.

AB - Two children taking valproic acid (VPA) developed renal Fanconi syndrome, a clinically subtle and potentially dangerous disorder. Discontinuation of VPA was associated with complete recovery of renal tubular function in 1 patient. A study of 100 children taking VPA did not identify another youngster with this complication, suggesting the maximum risk is less than 3%. Children who suffered perinatal anoxia and those taking VPA as opposed to divalproex sodium may be at increased risk. We recommend screening children receiving VPA for this potentially reversible renal tubulopathy.

KW - Children

KW - Fanconi syndrome

KW - Renal

KW - Valproic acid

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JO - Journal of Epilepsy

JF - Journal of Epilepsy

IS - 1

ER -

Occurrence of renal Fanconi syndrome in children on valproic acid therapy

Abstract

Keywords

ASJC Scopus subject areas

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