Occurrence of renal Fanconi syndrome in children on valproic acid therapy

Stephen J. Ryan, Nancy A. Bishof, Robert J. Baumann

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Two children taking valproic acid (VPA) developed renal Fanconi syndrome, a clinically subtle and potentially dangerous disorder. Discontinuation of VPA was associated with complete recovery of renal tubular function in 1 patient. A study of 100 children taking VPA did not identify another youngster with this complication, suggesting the maximum risk is less than 3%. Children who suffered perinatal anoxia and those taking VPA as opposed to divalproex sodium may be at increased risk. We recommend screening children receiving VPA for this potentially reversible renal tubulopathy.

Original languageEnglish
Pages (from-to)35-38
Number of pages4
JournalJournal of Epilepsy
Issue number1
StatePublished - 1996


  • Children
  • Fanconi syndrome
  • Renal
  • Valproic acid

ASJC Scopus subject areas

  • Neuroscience (all)
  • Clinical Neurology


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