TY - JOUR
T1 - Odor conditioning with morphine
T2 - Conditioned preference, aversion, and analgesia
AU - Randall, Christopher K.
AU - Kraemer, Philipp J.
AU - Valone, Joanne M.
AU - Bardo, Michael T.
PY - 1993/9
Y1 - 1993/9
N2 - The dose-dependent effects of morphine on odor conditioning in rats were examined in two experiments. Subjects received one odor paired with either a low dose of morphine (0.5 mg/kg; Experiment 1A) or a high dose of morphine (10.0 mg/kg; Experiment 1B), alternating with another odor paired with saline. In Experiment 1A, subjects spent significantly more time over the morphine-paired odor than over the saline-paired odor in a spatial-odor preference test (odor preference). In Experiment 1B, subjects spent significantly less time over the morphine-paired odor than over the saline-paired odor (odor aversion). In Experiment 2, pairing an odor with a high dose of morphine (10.0 mg/kg) produced a conditioned analgesic response, measured by paw-lick latency. These studies demonstrate that an odor may serve as an effective stimulus to which the motivational and analgesic effects of morphine can be conditioned.
AB - The dose-dependent effects of morphine on odor conditioning in rats were examined in two experiments. Subjects received one odor paired with either a low dose of morphine (0.5 mg/kg; Experiment 1A) or a high dose of morphine (10.0 mg/kg; Experiment 1B), alternating with another odor paired with saline. In Experiment 1A, subjects spent significantly more time over the morphine-paired odor than over the saline-paired odor in a spatial-odor preference test (odor preference). In Experiment 1B, subjects spent significantly less time over the morphine-paired odor than over the saline-paired odor (odor aversion). In Experiment 2, pairing an odor with a high dose of morphine (10.0 mg/kg) produced a conditioned analgesic response, measured by paw-lick latency. These studies demonstrate that an odor may serve as an effective stimulus to which the motivational and analgesic effects of morphine can be conditioned.
UR - http://www.scopus.com/inward/record.url?scp=0027247852&partnerID=8YFLogxK
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U2 - 10.3758/BF03327137
DO - 10.3758/BF03327137
M3 - Article
AN - SCOPUS:0027247852
VL - 21
SP - 215
EP - 220
IS - 3
ER -