OleD Loki as a Catalyst for Tertiary Amine and Hydroxamate Glycosylation

Ryan R. Hughes, Khaled A. Shaaban, Jianjun Zhang, Hongnan Cao, George N. Phillips, Jon S. Thorson

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


We describe the ability of an engineered glycosyltransferase (OleD Loki) to catalyze the N-glycosylation of tertiary-amine-containing drugs and trichostatin hydroxamate glycosyl ester formation. As such, this study highlights the first bacterial model catalyst for tertiary-amine N-glycosylation and further expands the substrate scope and synthetic potential of engineered OleDs. In addition, this work could open the door to the discovery of similar capabilities among other permissive bacterial glycosyltransferases.

Original languageEnglish
Pages (from-to)363-367
Number of pages5
Issue number4
StatePublished - Feb 16 2017

Bibliographical note

Publisher Copyright:
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim


  • antidepressants
  • drug metabolism
  • glucuronidation
  • glycosyltransferases
  • trichostatin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry


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