Olfactory Insights from Transcriptional Profiling

T. S. McClintock, N. Sammeta

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Olfactory sensory neurons and the process of adult neurogenesis have been major targets for expression profiling studies in the olfactory system. The >10. 000. mRNAs identified in olfactory sensory neurons predict responses to an unusually wide variety of intercellular signals, participation in diverse cell adhesion relationships, use of chromatin remodeling for functions not yet understood, robust stress response pathways, ciliogenesis, and control of gene expression through >250 transcription factors. Transcriptional changes during adult olfactory neurogenesis reveal molecular mechanisms supporting apoptosis of damaged neurons, infiltration of immune cells, proliferation of progenitor cells, and differentiation of new sensory neurons.

Original languageEnglish
Title of host publicationEncyclopedia of Neuroscience
Number of pages7
StatePublished - 2009


  • Adult neurogenesis
  • Bioinformatics
  • Chromatin remodeling
  • Cilia
  • Ciliogenesis
  • Expression profiling
  • Gene expression
  • Genomics
  • Microarray
  • Neural development
  • Neurogenesis
  • Odorant receptor
  • Olfaction
  • Smell
  • Transcription factor

ASJC Scopus subject areas

  • General Neuroscience


Dive into the research topics of 'Olfactory Insights from Transcriptional Profiling'. Together they form a unique fingerprint.

Cite this