Olfactory Insights from Transcriptional Profiling

T. S. McClintock; N. Sammeta

doi:10.1016/B978-008045046-9.00189-3

Olfactory Insights from Transcriptional Profiling

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Olfactory sensory neurons and the process of adult neurogenesis have been major targets for expression profiling studies in the olfactory system. The >10000mRNAs identified in olfactory sensory neurons predict responses to an unusually wide variety of intercellular signals, participation in diverse cell adhesion relationships, use of chromatin remodeling for functions not yet understood, robust stress response pathways, ciliogenesis, and control of gene expression through >250 transcription factors. Transcriptional changes during adult olfactory neurogenesis reveal molecular mechanisms supporting apoptosis of damaged neurons, infiltration of immune cells, proliferation of progenitor cells, and differentiation of new sensory neurons.

Original language	English
Title of host publication	Encyclopedia of Neuroscience
Subtitle of host publication	Volumes 1-11
Pages	V8-137-V8-143
Volume	8
ISBN (Electronic)	9780080450469
DOIs	https://doi.org/10.1016/B978-008045046-9.00189-3
State	Published - Jan 1 2009

Bibliographical note

Publisher Copyright:
© 2009 Elsevier Ltd. All rights reserved.

Keywords

Adult neurogenesis
Bioinformatics
Chromatin remodeling
Cilia
Ciliogenesis
Expression profiling
Gene expression
Genomics
Microarray
Neural development
Neurogenesis
Odorant receptor
Olfaction
Smell
Transcription factor

ASJC Scopus subject areas

General Medicine
General Neuroscience

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10.1016/B978-008045046-9.00189-3

Cite this

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Olfactory Insights from Transcriptional Profiling

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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