Omega-3 fatty acid effect on alveolar bone loss in rats

L. Kesavalu, B. Vasudevan, B. Raghu, E. Browning, D. Dawson, J. M. Novak, M. C. Correll, M. J. Steffen, A. Bhattacharya, G. Fernandes, J. L. Ebersole

    Research output: Contribution to journalArticlepeer-review

    71 Scopus citations


    Gingival inflammation and alveolar bone resorption are hallmarks of adult periodontitis, elicited in response to oral micro-organisms such as Porphyromonas gingivalis. We hypothesized that omega (ω)-3 fatty acids (FA) dietary supplementation would modulate inflammatory reactions leading to periodontal disease in infected rats. Rats were fed fish oil (ω-3 FA) or corn oil (n-6 FA) diets for 22 weeks and were infected with P. gingivalis. Rats on the ω-3 FA diet exhibited elevated serum levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), documenting diet-induced changes. PCR analyses demonstrated that rats were orally colonized by P. gingivalis; increased IgG antibody levels substantiated this infection. P. gingivalis-infected rats treated with ω-3 FA had significantly less alveolar bone resorption. These results demonstrated the effectiveness of an ω-3 FA-supplemented diet in modulating alveolar bone resorption following P. gingivalis infection, and supported that ω-3 FA may be a useful adjunct in the treatment of periodontal disease.

    Original languageEnglish
    Pages (from-to)648-652
    Number of pages5
    JournalJournal of Dental Research
    Issue number7
    StatePublished - Jul 2006

    Bibliographical note

    Funding Information:
    This investigation was supported by USPHS Research Grant DE-014896 from the National Institute of Dental and Craniofacial Research (LK) and Grant AG-23648 from the National Institute of Aging (GF), National Institutes of Health, Bethesda, MD 20892.


    • Alveolar bone loss
    • IgG antibody
    • P. gingivalis
    • Periodontal disease
    • ω-3 PUFA

    ASJC Scopus subject areas

    • General Dentistry


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