Abstract
Gingival inflammation and alveolar bone resorption are hallmarks of adult periodontitis, elicited in response to oral micro-organisms such as Porphyromonas gingivalis. We hypothesized that omega (ω)-3 fatty acids (FA) dietary supplementation would modulate inflammatory reactions leading to periodontal disease in infected rats. Rats were fed fish oil (ω-3 FA) or corn oil (n-6 FA) diets for 22 weeks and were infected with P. gingivalis. Rats on the ω-3 FA diet exhibited elevated serum levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), documenting diet-induced changes. PCR analyses demonstrated that rats were orally colonized by P. gingivalis; increased IgG antibody levels substantiated this infection. P. gingivalis-infected rats treated with ω-3 FA had significantly less alveolar bone resorption. These results demonstrated the effectiveness of an ω-3 FA-supplemented diet in modulating alveolar bone resorption following P. gingivalis infection, and supported that ω-3 FA may be a useful adjunct in the treatment of periodontal disease.
| Original language | English |
|---|---|
| Pages (from-to) | 648-652 |
| Number of pages | 5 |
| Journal | Journal of Dental Research |
| Volume | 85 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 2006 |
Bibliographical note
Funding Information:This investigation was supported by USPHS Research Grant DE-014896 from the National Institute of Dental and Craniofacial Research (LK) and Grant AG-23648 from the National Institute of Aging (GF), National Institutes of Health, Bethesda, MD 20892.
Keywords
- Alveolar bone loss
- IgG antibody
- P. gingivalis
- Periodontal disease
- ω-3 PUFA
ASJC Scopus subject areas
- General Dentistry