On the acceptor substrate of C-glycosyl-transferase UrdGT2: Three prejadomycin C-glycosides from an engineered mutant of Streptomyces globisporus 1912 ΔlndE(urdGT2)

Irfan Baig, Madan Kharel, Anton Kobylyanskyy, Lili Zhu, Yuriy Rebets, Bohdan Ostash, Andriy Luzhetskyy, Andreas Bechthold, Victor A. Fedorenko, Jürgen Rohr

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

(Chemical Equation Presented) The transfer of the gene urdGT2, which encodes a C-glycosyltransferase in the urdamycin pathway, into the lnd-minus mutant of the landomycin (lnd) biosynthetic pathway indicates the difference in the first glycosylation step in the urdamycin and landomycin pathways. It also reveals indirectly the acceptor substrate of UrdGT2 (see scheme) and gives evidence of greatly relaxed substrate specificity of all lnd glycosyltransferases except LndGT2.

Original languageEnglish
Pages (from-to)7842-7846
Number of pages5
JournalAngewandte Chemie - International Edition
Volume45
Issue number46
DOIs
StatePublished - Nov 27 2006

Keywords

  • Biosynthesis
  • Combinatorial biosynthesis
  • Glycosides
  • Landomycins
  • Polyketides

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry

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