On the Nature of the Intra-Administration Unconditioned Stimulus: Comment on McDonald and Siegel (2004)

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3 Scopus citations

Abstract

R. V. McDonald and S. Siegel (2004) present convincing evidence that a small dose of morphine (5 mg/kg) may elicit withdrawal signs in rats previously injected on a number of occasions with a large dose of morphine (50 mg/kg), thus suggesting that intra-administration associations may be involved in drug withdrawal. This finding is important for basic and applied researchers studying drug reward mechanisms. Although R. V. McDonald and S. Siegel (2004) point out that the morphine conditional stimulus (CS) and unconditioned stimulus (US) making up the intra-administration association differ in onset and magnitude, the author of this comment argues that the CS and US may also differ in terms of pharmacologic activity.

Original languageEnglish
Pages (from-to)12-14
Number of pages3
JournalExperimental and Clinical Psychopharmacology
Volume12
Issue number1
DOIs
StatePublished - Feb 2004

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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