Abstract
Cone-beam computed tomography (CT)-guided volumetric-modulated arc therapy (VMAT) plans for stereotactic body radiotherapy (SBRT) treatment of synchronous multiple lung lesions with a flattening filter-free (FFF) beam is a safe and highly effective treatment option for oligometastases lung cancer patients. Fourteen patients with metastatic non–small-cell lung cancer (NSCLC) lesions (two to five) received a single-isocenter VMAT SBRT treatment in our clinic. Four-dimensional (4D) CT-based treatment plans were generated using advanced AcurosXB-based dose calculation algorithm using heterogeneity corrections with a single isocenter placed between/among the lesions. Compared to 10X-FFF and traditional flattened 6X (6X-FF) beams, 6X-FFF beam produced highly conformal radiosurgical dose distribution to each target volume, reduced dose to adjacent organs at risk (OAR), and significantly reduced the lung SBRT fraction duration to < 3.5 min/fraction for 54/50 Gy treatments in 3/5 fractions — significantly improving patient convenience and clinic workflow. Early follow-up CT imaging (mean, 9 months) results show high local control rates (100%) with no acute lung or rib toxicity. Longer clinical follow up in a larger patient cohort is ongoing to further validate the outcomes of this treatment approach.
Original language | English |
---|---|
Pages (from-to) | 160-167 |
Number of pages | 8 |
Journal | Journal of Applied Clinical Medical Physics |
Volume | 21 |
Issue number | 8 |
DOIs | |
State | Published - Aug 1 2020 |
Bibliographical note
Publisher Copyright:© 2020 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.
Keywords
- FFF beams
- clinical outcomes
- lung SBRT
- oligometastastic lesions
- single-isocenter VMAT
ASJC Scopus subject areas
- Radiation
- Instrumentation
- Radiology Nuclear Medicine and imaging