Chromosomal translocations encode oncogenic fusion proteins that have been proven to be causally involved in tumorigenesis. Our understanding of whether such genomic alterations also affect non-coding RNAs is limited, and their impact on circular RNAs (circRNAs) has not been explored. Here, we show that well-established cancer-associated chromosomal translocations give rise to fusion circRNAs (f-circRNA) that are produced from transcribed exons of distinct genes affected by the translocations. F-circRNAs contribute to cellular transformation, promote cell viability and resistance upon therapy, and have tumor-promoting properties in in vivo models. Our work expands the current knowledge regarding molecular mechanisms involved in cancer onset and progression, with potential diagnostic and therapeutic implications.
|Number of pages||14|
|State||Published - Apr 7 2016|
Bibliographical noteFunding Information:
We thank Lauren Southwood and Kaitlyn Doherty for insightful editing and all members of the Pandolfi lab for critical discussion. We thank Dr. Daniel Costa for providing H3122 cell line and Dr. Mireia Castillo Martin for providing SKNEP cell line. J.G. was supported by a fellowship from American- Italian Cancer Foundation during the execution of this work. S.V.P. has been granted leave of absence from the German Cancer Research Center DKFZ, Heidelberg.
© 2016 Elsevier Inc.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology (all)