Oncometabolite modification of Keap1 links GSTZ1 deficiency with cancer

Weijie Guo; Binhua P. Zhou

doi:10.1016/j.gendis.2019.10.005

Oncometabolite modification of Keap1 links GSTZ1 deficiency with cancer

Weijie Guo, Binhua P. Zhou

Research output: Contribution to journal › Comment/debate

4 Scopus citations

Abstract

Metabolic abnormalities are emerging as an active driver to the development, progression and metastasis of various tumors. In the recent issue of the EMBO Journal, Yang and colleagues identified that succinylacetone (SA) could act as an oncometabolite and that accumulation of SA activates the NRF2/IGF1R axis in hepatocellular carcinoma (HCC) development. These discoveries not only yield great insights in the understanding of tumor biology, but also hold significant clinical ramifications, as these findings may pave a new way for the early diagnosis and treatment of HCC.

Original language	English
Pages (from-to)	333-334
Number of pages	2
Journal	Genes and Diseases
Volume	6
Issue number	4
DOIs	https://doi.org/10.1016/j.gendis.2019.10.005
State	Published - Dec 2019

Bibliographical note

Publisher Copyright:
© 2019 Chongqing Medical University

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Genetics(clinical)
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.gendis.2019.10.005

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title = "Oncometabolite modification of Keap1 links GSTZ1 deficiency with cancer",

abstract = "Metabolic abnormalities are emerging as an active driver to the development, progression and metastasis of various tumors. In the recent issue of the EMBO Journal, Yang and colleagues identified that succinylacetone (SA) could act as an oncometabolite and that accumulation of SA activates the NRF2/IGF1R axis in hepatocellular carcinoma (HCC) development. These discoveries not only yield great insights in the understanding of tumor biology, but also hold significant clinical ramifications, as these findings may pave a new way for the early diagnosis and treatment of HCC.",

author = "Weijie Guo and Zhou, {Binhua P.}",

note = "Publisher Copyright: {\textcopyright} 2019 Chongqing Medical University",

year = "2019",

month = dec,

doi = "10.1016/j.gendis.2019.10.005",

language = "English",

volume = "6",

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}

TY - JOUR

T1 - Oncometabolite modification of Keap1 links GSTZ1 deficiency with cancer

AU - Guo, Weijie

AU - Zhou, Binhua P.

PY - 2019/12

Y1 - 2019/12

N2 - Metabolic abnormalities are emerging as an active driver to the development, progression and metastasis of various tumors. In the recent issue of the EMBO Journal, Yang and colleagues identified that succinylacetone (SA) could act as an oncometabolite and that accumulation of SA activates the NRF2/IGF1R axis in hepatocellular carcinoma (HCC) development. These discoveries not only yield great insights in the understanding of tumor biology, but also hold significant clinical ramifications, as these findings may pave a new way for the early diagnosis and treatment of HCC.

AB - Metabolic abnormalities are emerging as an active driver to the development, progression and metastasis of various tumors. In the recent issue of the EMBO Journal, Yang and colleagues identified that succinylacetone (SA) could act as an oncometabolite and that accumulation of SA activates the NRF2/IGF1R axis in hepatocellular carcinoma (HCC) development. These discoveries not only yield great insights in the understanding of tumor biology, but also hold significant clinical ramifications, as these findings may pave a new way for the early diagnosis and treatment of HCC.

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DO - 10.1016/j.gendis.2019.10.005

M3 - Comment/debate

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SN - 2352-4820

VL - 6

SP - 333

EP - 334

JO - Genes and Diseases

JF - Genes and Diseases

IS - 4

ER -

Oncometabolite modification of Keap1 links GSTZ1 deficiency with cancer

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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