TY - JOUR
T1 - One-Pot Enzymatic Total Synthesis of Presteffimycinone, an Early Intermediate of the Anthracycline Antibiotic Steffimycin Biosynthesis
AU - Wang, Guojun
AU - Chen, Jing
AU - Zhu, Haining
AU - Rohr, Jürgen
N1 - Publisher Copyright:
© 2017 American Chemical Society.
PY - 2017/2/3
Y1 - 2017/2/3
N2 - Early acting cyclases play critical roles in programming the polyketide biosynthesis toward certain, distinguished scaffolds. Starting from acetyl-CoA and malonyl-CoA, a one-pot enzymatic total synthesis of an anthracyclinone scaffold, presteffimycinone, was achieved by mixing polyketide synthase (PKS) and early post-PKS enzymes from the biosynthetic pathways of three different types of type II-PKS driven anticancer antibiotics, namely, the mithramycin (aureolic acid-type), gilvocarcin (rearranged angucycline-type), and steffimycin (anthracycline) pathways.
AB - Early acting cyclases play critical roles in programming the polyketide biosynthesis toward certain, distinguished scaffolds. Starting from acetyl-CoA and malonyl-CoA, a one-pot enzymatic total synthesis of an anthracyclinone scaffold, presteffimycinone, was achieved by mixing polyketide synthase (PKS) and early post-PKS enzymes from the biosynthetic pathways of three different types of type II-PKS driven anticancer antibiotics, namely, the mithramycin (aureolic acid-type), gilvocarcin (rearranged angucycline-type), and steffimycin (anthracycline) pathways.
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U2 - 10.1021/acs.orglett.6b03708
DO - 10.1021/acs.orglett.6b03708
M3 - Article
C2 - 28102686
AN - SCOPUS:85011397682
SN - 1523-7060
VL - 19
SP - 540
EP - 543
JO - Organic Letters
JF - Organic Letters
IS - 3
ER -