Abstract
Early acting cyclases play critical roles in programming the polyketide biosynthesis toward certain, distinguished scaffolds. Starting from acetyl-CoA and malonyl-CoA, a one-pot enzymatic total synthesis of an anthracyclinone scaffold, presteffimycinone, was achieved by mixing polyketide synthase (PKS) and early post-PKS enzymes from the biosynthetic pathways of three different types of type II-PKS driven anticancer antibiotics, namely, the mithramycin (aureolic acid-type), gilvocarcin (rearranged angucycline-type), and steffimycin (anthracycline) pathways.
| Original language | English |
|---|---|
| Pages (from-to) | 540-543 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 19 |
| Issue number | 3 |
| DOIs | |
| State | Published - Feb 3 2017 |
Bibliographical note
Publisher Copyright:© 2017 American Chemical Society.
Funding
This work was supported by NIH grants CA 091901 and GM 105977 to J.R., and the Start-Up package provided by Florida Atlantic University Harbor Branch Oceanographic Institute Foundation to G.W. We thank Dr. Yi Tang, UCLA, for providing us the construct for MatB-expression.
| Funders | Funder number |
|---|---|
| Florida Atlantic University Harbor Branch Oceanographic Institute Foundation | |
| National Institutes of Health (NIH) | GM 105977, CA 091901 |
| National Childhood Cancer Registry – National Cancer Institute | R21CA209189 |
| University of California, Los Angeles |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry