TY - JOUR
T1 - Ontogenetic changes in dopaminergic pre and postsynaptic elements in rat brain
T2 - Effects of quinpirole and sulpiride
AU - McDougall, S. A.
AU - Bardo, M. T.
PY - 1991/5
Y1 - 1991/5
N2 - The effects of quinpirole and sulpiride on dopamine (DA), dihydroxyphenylacetic acid (DOPAC) and accumulation of dihydroxyphenylalanine (DOPA) after inhibition of DOPA decarboxylase were determined for the striatum and tegmentum of 11- and 17-day-old rat pups. In both 11- and 17-day-olds, sulpiride enhanced striatal DOPAC and DOPA accumulation; whereas, quinpirole decreased DOPAC levels and increased DA levels. In the tegmentum, sulpiride enhanced DOPA accumulation in the 11-day-olds only. 3H-spiroperidol binding sites were also measured in the striatum, nucleus accumbens, tegmentum, medial frontal cortex, and the hippocampo-entorhinal area of 11- and 17-day-old pups. Age-dependent increases in binding site density were found in the striatum and nucleus accumbens.
AB - The effects of quinpirole and sulpiride on dopamine (DA), dihydroxyphenylacetic acid (DOPAC) and accumulation of dihydroxyphenylalanine (DOPA) after inhibition of DOPA decarboxylase were determined for the striatum and tegmentum of 11- and 17-day-old rat pups. In both 11- and 17-day-olds, sulpiride enhanced striatal DOPAC and DOPA accumulation; whereas, quinpirole decreased DOPAC levels and increased DA levels. In the tegmentum, sulpiride enhanced DOPA accumulation in the 11-day-olds only. 3H-spiroperidol binding sites were also measured in the striatum, nucleus accumbens, tegmentum, medial frontal cortex, and the hippocampo-entorhinal area of 11- and 17-day-old pups. Age-dependent increases in binding site density were found in the striatum and nucleus accumbens.
KW - H-spiroperidol
KW - dopamine metabolites
KW - ontogeny
KW - quinpirole
KW - sulpiride
UR - http://www.scopus.com/inward/record.url?scp=0025922698&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025922698&partnerID=8YFLogxK
U2 - 10.1016/0028-3908(91)90017-6
DO - 10.1016/0028-3908(91)90017-6
M3 - Article
C2 - 1678147
AN - SCOPUS:0025922698
SN - 0028-3908
VL - 30
SP - 531
EP - 534
JO - Neuropharmacology
JF - Neuropharmacology
IS - 5
ER -