Ontogeny of Receptor Binding Sites for [3H]Glutamic Acid and [3H]Kainic Acid in the Rat Cerebellum

J. T. Slevin, J. T. Coyle

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Abstract: The development of the specific binding sites for l‐[3H]glutamic acid (KD= 370 nM) and for [3H]kainic acid (KD= 39 nM) was studied in the rat cerebellum. Specific binding at both sites remains low during the first week after birth but increases markedly during the second and third weeks after birth, when glutamatergic parallel fiber synaptogenesis occurs. The development of the kainate site lags behind that of the glutamate site, indicating their autonomy.

Original languageEnglish
Pages (from-to)531-533
Number of pages3
JournalJournal of Neurochemistry
Volume37
Issue number2
DOIs
StatePublished - Aug 1981

Keywords

  • Binding sites
  • Rat cerebellum
  • Receptor
  • [H]Kainic acid
  • l‐[H]Glutamic acid

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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