Ontogeny of Receptor Binding Sites for [3H]Glutamic Acid and [3H]Kainic Acid in the Rat Cerebellum

J. T. Slevin; J. T. Coyle

doi:10.1111/j.1471-4159.1981.tb00491.x

Ontogeny of Receptor Binding Sites for [³H]Glutamic Acid and [³H]Kainic Acid in the Rat Cerebellum

J. T. Slevin, J. T. Coyle

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Abstract: The development of the specific binding sites for l‐[³H]glutamic acid (K_D= 370 nM) and for [³H]kainic acid (K_D= 39 nM) was studied in the rat cerebellum. Specific binding at both sites remains low during the first week after birth but increases markedly during the second and third weeks after birth, when glutamatergic parallel fiber synaptogenesis occurs. The development of the kainate site lags behind that of the glutamate site, indicating their autonomy.

Original language	English
Pages (from-to)	531-533
Number of pages	3
Journal	Journal of Neurochemistry
Volume	37
Issue number	2
DOIs	https://doi.org/10.1111/j.1471-4159.1981.tb00491.x
State	Published - Aug 1981

Keywords

Binding sites
l‐[H]Glutamic acid
Rat cerebellum
Receptor
[H]Kainic acid

ASJC Scopus subject areas

Biochemistry
Cellular and Molecular Neuroscience

Access to Document

10.1111/j.1471-4159.1981.tb00491.x

Cite this

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abstract = "Abstract: The development of the specific binding sites for l‐[3H]glutamic acid (KD= 370 nM) and for [3H]kainic acid (KD= 39 nM) was studied in the rat cerebellum. Specific binding at both sites remains low during the first week after birth but increases markedly during the second and third weeks after birth, when glutamatergic parallel fiber synaptogenesis occurs. The development of the kainate site lags behind that of the glutamate site, indicating their autonomy.",

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AB - Abstract: The development of the specific binding sites for l‐[3H]glutamic acid (KD= 370 nM) and for [3H]kainic acid (KD= 39 nM) was studied in the rat cerebellum. Specific binding at both sites remains low during the first week after birth but increases markedly during the second and third weeks after birth, when glutamatergic parallel fiber synaptogenesis occurs. The development of the kainate site lags behind that of the glutamate site, indicating their autonomy.

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