Opiate receptor ontogeny and morphine-induced effects: Influence of chronic footshock stress in preweanling rats

M. T. Bardo, R. K. Bhatnagar, G. F. Gebhart

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

The ontogeny of opiate receptors was examined in various CNS regions of preweanling rats which received either daily inescapable footshock stress, exposure to a footshock apparatus without shock, or no handling from birth to 21 days of age. At 21 days of age, each of these treatment groups was also assessed for morphine-induced changes in activity, hot-plate paw-lick latency, and core body temperature. Marked regional differences in [3H]naloxone binding capacity were observed from 7 to 21 days of age in spinal cord, medulla-pons, midbrain, hypothalamus, striatum, and cortex. Caudal regions approached adult-like [3H]naloxone binding before rostral regions. The normal ontogeny of opiate receptors was not significantly influenced by the chronic footshock treatment. However, footshock treatment significantly reduced the efficacy of morphine (2 mg/kg) in producing hypoactive and antinociceptive effects, but not in producing a hyperthermic effect. These results demonstrate that stress-related changes in the behavioral efficacy of morphine do not necessarily depend upon changes in those opiate receptor populations that bind naloxone.

Original languageEnglish
Pages (from-to)487-495
Number of pages9
JournalDevelopmental Brain Research
Volume1
Issue number4
DOIs
StatePublished - Jul 1981

Keywords

  • antinociception
  • footshock stress
  • hyperthermia
  • hypoactivity
  • morphine
  • opiate receptor
  • preweanling development

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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