TY - JOUR
T1 - Opioid craving does not incubate over time in inpatient or outpatient treatment studies
T2 - Is the preclinical incubation of craving model lost in translation?
AU - Bergeria, Cecilia L.
AU - Gipson, Cassandra D.
AU - Smith, Kirsten E.
AU - Stoops, William W.
AU - Strickland, Justin C.
N1 - Publisher Copyright:
© 2024 Elsevier Ltd
PY - 2024/5
Y1 - 2024/5
N2 - Within addiction science, incubation of craving is an operational label used to describe time-dependent increases in drug seeking during periods of drug deprivation. The purpose of this systematic review was to describe the preclinical literature on incubation of craving and the clinical literature on craving measured over extended periods of abstinence to document this translational homology and factors impacting correspondence. Across the 44 preclinical studies that met inclusion criteria, 31 reported evidence of greater lever pressing, nose pokes, spout licks, or time spent in drug-paired compartments (i.e., drug seeking) relative to neutral compartments after longer periods of abstinence relative to shorter periods of abstinence, labelled as “incubation of craving.” In contrast, no clinical studies (n = 20) identified an increase in opioid craving during longer abstinence periods. The lack of clinical evidence for increases in craving in clinical populations weakens the translational utility of operationalizing the time-dependent increase in drug-seeking behavior observed in preclinical models as models of incubation of “craving”.
AB - Within addiction science, incubation of craving is an operational label used to describe time-dependent increases in drug seeking during periods of drug deprivation. The purpose of this systematic review was to describe the preclinical literature on incubation of craving and the clinical literature on craving measured over extended periods of abstinence to document this translational homology and factors impacting correspondence. Across the 44 preclinical studies that met inclusion criteria, 31 reported evidence of greater lever pressing, nose pokes, spout licks, or time spent in drug-paired compartments (i.e., drug seeking) relative to neutral compartments after longer periods of abstinence relative to shorter periods of abstinence, labelled as “incubation of craving.” In contrast, no clinical studies (n = 20) identified an increase in opioid craving during longer abstinence periods. The lack of clinical evidence for increases in craving in clinical populations weakens the translational utility of operationalizing the time-dependent increase in drug-seeking behavior observed in preclinical models as models of incubation of “craving”.
KW - Craving
KW - Heroin
KW - Models
KW - Opioid
KW - Treatment
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UR - http://www.scopus.com/inward/citedby.url?scp=85187959530&partnerID=8YFLogxK
U2 - 10.1016/j.neubiorev.2024.105618
DO - 10.1016/j.neubiorev.2024.105618
M3 - Review article
C2 - 38492446
AN - SCOPUS:85187959530
SN - 0149-7634
VL - 160
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
M1 - 105618
ER -