Opioid mediation of cocaine-induced hyperactivity and reinforcement

Abdulghani A. Houdi, Michael T. Bardo, Glen R. Van Loon

Research output: Contribution to journalArticlepeer-review

99 Scopus citations


The mechanisms by which cocaine produces hyperactivity and reinforcement remain poorly understood. Since reinforcement is also a property of other drugs of abuse including opiates, we examined the possible mediation of these cocaine-induced behaviors by endogenous opioid peptides. In this study, we have confirmed reports that cocaine increases locomotor activity and conditioned place preference in rats. We have also demonstrated that opioid receptor blockade with naloxone antagonizes completely the locomotor-activating effect of cocaine and attenuates the strength of the place preference conditioning produced by cocaine. These data support the thesis that endogenous opioids are involved in mediation of cocaine-induced behavior.

Original languageEnglish
Pages (from-to)195-198
Number of pages4
JournalBrain Research
Issue number1
StatePublished - Sep 11 1989

Bibliographical note

Funding Information:
These studies were supported by the Veterans Administration and the University of Kentucky Tobacco and Health Research Institute.


  • Cocaine
  • Conditioned place preference
  • Locomotor activity
  • Opioid peptide, endogenous
  • Reinforcement

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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