Opioid mediation of cocaine-induced hyperactivity and reinforcement

Abdulghani A. Houdi; Michael T. Bardo; Glen R. Van Loon

doi:10.1016/0006-8993(89)90989-X

Opioid mediation of cocaine-induced hyperactivity and reinforcement

Abdulghani A. Houdi
, Michael T. Bardo
, Glen R. Van Loon

Research output: Contribution to journal › Article › peer-review

99 Scopus citations

Abstract

The mechanisms by which cocaine produces hyperactivity and reinforcement remain poorly understood. Since reinforcement is also a property of other drugs of abuse including opiates, we examined the possible mediation of these cocaine-induced behaviors by endogenous opioid peptides. In this study, we have confirmed reports that cocaine increases locomotor activity and conditioned place preference in rats. We have also demonstrated that opioid receptor blockade with naloxone antagonizes completely the locomotor-activating effect of cocaine and attenuates the strength of the place preference conditioning produced by cocaine. These data support the thesis that endogenous opioids are involved in mediation of cocaine-induced behavior.

Original language	English
Pages (from-to)	195-198
Number of pages	4
Journal	Brain Research
Volume	497
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(89)90989-X
State	Published - Sep 11 1989

Bibliographical note

Funding Information:
These studies were supported by the Veterans Administration and the University of Kentucky Tobacco and Health Research Institute.

Funding

These studies were supported by the Veterans Administration and the University of Kentucky Tobacco and Health Research Institute.

Funders
Tobacco and Health Research Institute of the University of Kentucky
U.S. Department of Veterans Affairs

Keywords

Cocaine
Conditioned place preference
Locomotor activity
Opioid peptide, endogenous
Reinforcement

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(89)90989-X

Cite this

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title = "Opioid mediation of cocaine-induced hyperactivity and reinforcement",

abstract = "The mechanisms by which cocaine produces hyperactivity and reinforcement remain poorly understood. Since reinforcement is also a property of other drugs of abuse including opiates, we examined the possible mediation of these cocaine-induced behaviors by endogenous opioid peptides. In this study, we have confirmed reports that cocaine increases locomotor activity and conditioned place preference in rats. We have also demonstrated that opioid receptor blockade with naloxone antagonizes completely the locomotor-activating effect of cocaine and attenuates the strength of the place preference conditioning produced by cocaine. These data support the thesis that endogenous opioids are involved in mediation of cocaine-induced behavior.",

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author = "Houdi, \{Abdulghani A.\} and Bardo, \{Michael T.\} and \{Van Loon\}, \{Glen R.\}",

note = "Funding Information: These studies were supported by the Veterans Administration and the University of Kentucky Tobacco and Health Research Institute.",

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language = "English",

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AU - Bardo, Michael T.

AU - Van Loon, Glen R.

N1 - Funding Information: These studies were supported by the Veterans Administration and the University of Kentucky Tobacco and Health Research Institute.

PY - 1989/9/11

Y1 - 1989/9/11

N2 - The mechanisms by which cocaine produces hyperactivity and reinforcement remain poorly understood. Since reinforcement is also a property of other drugs of abuse including opiates, we examined the possible mediation of these cocaine-induced behaviors by endogenous opioid peptides. In this study, we have confirmed reports that cocaine increases locomotor activity and conditioned place preference in rats. We have also demonstrated that opioid receptor blockade with naloxone antagonizes completely the locomotor-activating effect of cocaine and attenuates the strength of the place preference conditioning produced by cocaine. These data support the thesis that endogenous opioids are involved in mediation of cocaine-induced behavior.

AB - The mechanisms by which cocaine produces hyperactivity and reinforcement remain poorly understood. Since reinforcement is also a property of other drugs of abuse including opiates, we examined the possible mediation of these cocaine-induced behaviors by endogenous opioid peptides. In this study, we have confirmed reports that cocaine increases locomotor activity and conditioned place preference in rats. We have also demonstrated that opioid receptor blockade with naloxone antagonizes completely the locomotor-activating effect of cocaine and attenuates the strength of the place preference conditioning produced by cocaine. These data support the thesis that endogenous opioids are involved in mediation of cocaine-induced behavior.

KW - Cocaine

KW - Conditioned place preference

KW - Locomotor activity

KW - Opioid peptide, endogenous

KW - Reinforcement

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Opioid mediation of cocaine-induced hyperactivity and reinforcement

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

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