Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects

Turgut Durduran; Chao Zhou; Erin M. Buckley; Meeri N. Kim; Guoqiang Yu; Regine Choe; J. William Gaynor; Thomas L. Spray; Suzanne M. Durning; Stefanie E. Mason; Lisa M. Montenegro; Susan C. Nicolson; Robert A. Zimmerman; Mary E. Putt; Jiongjiong Wang; Joel H. Greenberg; John A. Detre; Arjun G. Yodh; Daniel J. Licht

doi:10.1117/1.3425884

Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects

Turgut Durduran
, Chao Zhou
, Erin M. Buckley
, Meeri N. Kim
, Guoqiang Yu
, Regine Choe
, J. William Gaynor
, Thomas L. Spray
, Suzanne M. Durning
, Stefanie E. Mason
, Lisa M. Montenegro
, Susan C. Nicolson
, Robert A. Zimmerman
, Mary E. Putt
, Jiongjiong Wang
, Joel H. Greenberg
, John A. Detre
, Arjun G. Yodh
, Daniel J. Licht

Research output: Contribution to journal › Article › peer-review

169 Scopus citations

Abstract

We employ a hybrid diffuse correlation spectroscopy (DCS) and near-infrared spectroscopy (NIRS) monitor for neonates with congenital heart disease (n=33). The NIRS-DCS device measured changes during hypercapnia of oxyhemoglobin, deoxyhemoglobin, and total hemoglobin concentrations; cerebral blood flow (rCBFDCS); and oxygen metabolism (rCMRO ₂). Concurrent measurements with arterial spin-labeled magnetic resonance imaging (rCBF _ASL-MRI, n=12) cross-validate rCBFDCS against rCBF _ASL-MRI, showing good agreement (R=0.7, p=0.01). The study demonstrates use of NIRSDCS on a critically ill neonatal population, and the results indicate that the optical technology is a promising clinical method for monitoring this population.

Original language	English
Article number	037004
Journal	Journal of Biomedical Optics
Volume	15
Issue number	3
DOIs	https://doi.org/10.1117/1.3425884
State	Published - May 2010

Bibliographical note

Funding Information:
This study was supported by NIH Grant Nos. HL-57835, NS-60653, NS-45839, RR-02305, EB-007610, HL-077699, HD-26979, and NS-52380; Thrasher Research Fund (NR 0016); Fundació Cellex Barcelona; and June and Steve Wolfson Family Foundation. We acknowledge invaluable assistance from Dalton Hance and staff of the MRI facilities at Children’s Hospital of Philadelphia.

Funding

This study was supported by NIH Grant Nos. HL-57835, NS-60653, NS-45839, RR-02305, EB-007610, HL-077699, HD-26979, and NS-52380; Thrasher Research Fund (NR 0016); Fundació Cellex Barcelona; and June and Steve Wolfson Family Foundation. We acknowledge invaluable assistance from Dalton Hance and staff of the MRI facilities at Children’s Hospital of Philadelphia.

Funders	Funder number
National Institutes of Health (NIH)	EB-007610, HL-57835, HL-077699, NS-45839, HD-26979, NS-60653, RR-02305
National Institute of Neurological Disorders and Stroke	K23NS052380
Thrasher Research Fund	NR 0016
June and Steve Wolfson Family Foundation
Fundació Barcelona Zoo

Keywords

Cerebral blood flow
Congenital heart disease
Diffuse correlation spectroscopy
Diffuse optics
Near-infrared spectroscopy
Pediatrics

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Biomaterials
Atomic and Molecular Physics, and Optics
Biomedical Engineering

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10.1117/1.3425884

Cite this

Durduran, T., Zhou, C., Buckley, E. M., Kim, M. N., Yu, G., Choe, R., William Gaynor, J., Spray, T. L., Durning, S. M., Mason, S. E., Montenegro, L. M., Nicolson, S. C., Zimmerman, R. A., Putt, M. E., Wang, J., Greenberg, J. H., Detre, J. A., Yodh, A. G., & Licht, D. J. (2010). Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects. Journal of Biomedical Optics, 15(3), Article 037004. https://doi.org/10.1117/1.3425884

@article{f8d5f5eab1624cc2803fd42e113cf528,

title = "Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects",

abstract = "We employ a hybrid diffuse correlation spectroscopy (DCS) and near-infrared spectroscopy (NIRS) monitor for neonates with congenital heart disease (n=33). The NIRS-DCS device measured changes during hypercapnia of oxyhemoglobin, deoxyhemoglobin, and total hemoglobin concentrations; cerebral blood flow (rCBFDCS); and oxygen metabolism (rCMRO 2). Concurrent measurements with arterial spin-labeled magnetic resonance imaging (rCBF ASL-MRI, n=12) cross-validate rCBFDCS against rCBF ASL-MRI, showing good agreement (R=0.7, p=0.01). The study demonstrates use of NIRSDCS on a critically ill neonatal population, and the results indicate that the optical technology is a promising clinical method for monitoring this population.",

keywords = "Cerebral blood flow, Congenital heart disease, Diffuse correlation spectroscopy, Diffuse optics, Near-infrared spectroscopy, Pediatrics",

author = "Turgut Durduran and Chao Zhou and Buckley, \{Erin M.\} and Kim, \{Meeri N.\} and Guoqiang Yu and Regine Choe and \{William Gaynor\}, J. and Spray, \{Thomas L.\} and Durning, \{Suzanne M.\} and Mason, \{Stefanie E.\} and Montenegro, \{Lisa M.\} and Nicolson, \{Susan C.\} and Zimmerman, \{Robert A.\} and Putt, \{Mary E.\} and Jiongjiong Wang and Greenberg, \{Joel H.\} and Detre, \{John A.\} and Yodh, \{Arjun G.\} and Licht, \{Daniel J.\}",

note = "Funding Information: This study was supported by NIH Grant Nos. HL-57835, NS-60653, NS-45839, RR-02305, EB-007610, HL-077699, HD-26979, and NS-52380; Thrasher Research Fund (NR 0016); Fundaci{\'o} Cellex Barcelona; and June and Steve Wolfson Family Foundation. We acknowledge invaluable assistance from Dalton Hance and staff of the MRI facilities at Children{\textquoteright}s Hospital of Philadelphia.",

year = "2010",

month = may,

doi = "10.1117/1.3425884",

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Durduran, T, Zhou, C, Buckley, EM, Kim, MN, Yu, G, Choe, R, William Gaynor, J, Spray, TL, Durning, SM, Mason, SE, Montenegro, LM, Nicolson, SC, Zimmerman, RA, Putt, ME, Wang, J, Greenberg, JH, Detre, JA, Yodh, AG & Licht, DJ 2010, 'Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects', Journal of Biomedical Optics, vol. 15, no. 3, 037004. https://doi.org/10.1117/1.3425884

TY - JOUR

T1 - Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects

AU - Durduran, Turgut

AU - Zhou, Chao

AU - Buckley, Erin M.

AU - Kim, Meeri N.

AU - Yu, Guoqiang

AU - Choe, Regine

AU - William Gaynor, J.

AU - Spray, Thomas L.

AU - Durning, Suzanne M.

AU - Mason, Stefanie E.

AU - Montenegro, Lisa M.

AU - Nicolson, Susan C.

AU - Zimmerman, Robert A.

AU - Putt, Mary E.

AU - Wang, Jiongjiong

AU - Greenberg, Joel H.

AU - Detre, John A.

AU - Yodh, Arjun G.

AU - Licht, Daniel J.

N1 - Funding Information: This study was supported by NIH Grant Nos. HL-57835, NS-60653, NS-45839, RR-02305, EB-007610, HL-077699, HD-26979, and NS-52380; Thrasher Research Fund (NR 0016); Fundació Cellex Barcelona; and June and Steve Wolfson Family Foundation. We acknowledge invaluable assistance from Dalton Hance and staff of the MRI facilities at Children’s Hospital of Philadelphia.

PY - 2010/5

Y1 - 2010/5

N2 - We employ a hybrid diffuse correlation spectroscopy (DCS) and near-infrared spectroscopy (NIRS) monitor for neonates with congenital heart disease (n=33). The NIRS-DCS device measured changes during hypercapnia of oxyhemoglobin, deoxyhemoglobin, and total hemoglobin concentrations; cerebral blood flow (rCBFDCS); and oxygen metabolism (rCMRO 2). Concurrent measurements with arterial spin-labeled magnetic resonance imaging (rCBF ASL-MRI, n=12) cross-validate rCBFDCS against rCBF ASL-MRI, showing good agreement (R=0.7, p=0.01). The study demonstrates use of NIRSDCS on a critically ill neonatal population, and the results indicate that the optical technology is a promising clinical method for monitoring this population.

AB - We employ a hybrid diffuse correlation spectroscopy (DCS) and near-infrared spectroscopy (NIRS) monitor for neonates with congenital heart disease (n=33). The NIRS-DCS device measured changes during hypercapnia of oxyhemoglobin, deoxyhemoglobin, and total hemoglobin concentrations; cerebral blood flow (rCBFDCS); and oxygen metabolism (rCMRO 2). Concurrent measurements with arterial spin-labeled magnetic resonance imaging (rCBF ASL-MRI, n=12) cross-validate rCBFDCS against rCBF ASL-MRI, showing good agreement (R=0.7, p=0.01). The study demonstrates use of NIRSDCS on a critically ill neonatal population, and the results indicate that the optical technology is a promising clinical method for monitoring this population.

KW - Cerebral blood flow

KW - Congenital heart disease

KW - Diffuse correlation spectroscopy

KW - Diffuse optics

KW - Near-infrared spectroscopy

KW - Pediatrics

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UR - https://www.scopus.com/pages/publications/77953769306#tab=citedBy

U2 - 10.1117/1.3425884

DO - 10.1117/1.3425884

M3 - Article

C2 - 20615033

AN - SCOPUS:77953769306

SN - 1083-3668

VL - 15

JO - Journal of Biomedical Optics

JF - Journal of Biomedical Optics

IS - 3

M1 - 037004

ER -

Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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