Optically modulated fluorophores for selective fluorescence signal recovery

Chris I. Richards, Jung Cheng Hsiang, Dulal Senapati, Sandeep Patel, Junhua Yu, Tom Vosch, Robert M. Dickson

Research output: Contribution to journalArticlepeer-review

121 Scopus citations


Fluorescence imaging in biological sciences is hindered by significant depth-dependent signal attenuation and highly fluorescent backgrounds. We have developed optically modulated near-IR-emitting few-atom Ag nanodots that are selectively and dynamically photobrightened upon simultaneous excitation with a secondary laser, enabling high-sensitivity image extraction to reveal only the demodulated fluorophores. Image demodulation is demonstrated in high-background environments to extract weak signals from completely obscuring background emission.

Original languageEnglish
Pages (from-to)4619-4621
Number of pages3
JournalJournal of the American Chemical Society
Issue number13
StatePublished - Apr 8 2009

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry


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