Abstract
Fluorescence imaging in biological sciences is hindered by significant depth-dependent signal attenuation and highly fluorescent backgrounds. We have developed optically modulated near-IR-emitting few-atom Ag nanodots that are selectively and dynamically photobrightened upon simultaneous excitation with a secondary laser, enabling high-sensitivity image extraction to reveal only the demodulated fluorophores. Image demodulation is demonstrated in high-background environments to extract weak signals from completely obscuring background emission.
| Original language | English |
|---|---|
| Pages (from-to) | 4619-4621 |
| Number of pages | 3 |
| Journal | Journal of the American Chemical Society |
| Volume | 131 |
| Issue number | 13 |
| DOIs | |
| State | Published - Apr 8 2009 |
Funding
| Funders | Funder number |
|---|---|
| National Institute of General Medical Sciences | R01GM086195 |
ASJC Scopus subject areas
- Catalysis
- General Chemistry
- Biochemistry
- Colloid and Surface Chemistry
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