Optimal configuration of respiratory navigator gating for the quantification of left ventricular strain using spiral cine displacement encoding with stimulated echoes (DENSE) MRI

Sean M. Hamlet; Christopher M. Haggerty; Jonathan D. Suever; Gregory J. Wehner; Kristin N. Andres; David K. Powell; Xiaodong Zhong; Brandon K. Fornwalt

doi:10.1002/jmri.25389

Optimal configuration of respiratory navigator gating for the quantification of left ventricular strain using spiral cine displacement encoding with stimulated echoes (DENSE) MRI

Sean M. Hamlet, Christopher M. Haggerty, Jonathan D. Suever, Gregory J. Wehner, Kristin N. Andres, David K. Powell, Xiaodong Zhong, Brandon K. Fornwalt

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Purpose: To determine the optimal respiratory navigator gating configuration for the quantification of left ventricular strain using spiral cine displacement encoding with stimulated echoes (DENSE) MRI. Materials and Methods: Two-dimensional spiral cine DENSE was performed on a 3 Tesla MRI using two single-navigator configurations (retrospective, prospective) and a combined “dual-navigator” configuration in 10 healthy adults and 20 healthy children. The adults also underwent breathhold DENSE as a reference standard for comparisons. Peak left ventricular strains, signal-to-noise ratio (SNR), and navigator efficiency were compared. Subjects also underwent dual-navigator gating with and without visual feedback to determine the effect on navigator efficiency. Results: There were no differences in circumferential, radial, and longitudinal strains between navigator-gated and breathhold DENSE (P = 0.09–0.95) (as confidence intervals, retrospective: [-1.0%–1.1%], [-7.4%–2.0%], [-1.0%–1.2%]; prospective: [-0.6%–2.7%], [-2.8%–8.3%], [-0.3%–2.9%]; dual: [-1.6%–0.5%], [-8.3%–3.2%], [-0.8%–1.9%], respectively). The dual configuration maintained SNR compared with breathhold acquisitions (16 versus 18, P = 0.06). SNR for the prospective configuration was lower than for the dual navigator in adults (P = 0.004) and children (P < 0.001). Navigator efficiency was higher (P < 0.001) for both retrospective (54%) and prospective (56%) configurations compared with the dual configuration (35%). Visual feedback improved the dual configuration navigator efficiency to 55% (P < 0.001). Conclusion: When quantifying left ventricular strains using spiral cine DENSE MRI, a dual navigator configuration results in the highest SNR in adults and children. In adults, a retrospective configuration has good navigator efficiency without a substantial drop in SNR. Prospective gating should be avoided because it has the lowest SNR. Visual feedback represents an effective option to maintain navigator efficiency while using a dual navigator configuration. Level of Evidence: 2. J. Magn. Reson. Imaging 2017;45:786–794.

Original language	English
Pages (from-to)	786-794
Number of pages	9
Journal	Journal of Magnetic Resonance Imaging
Volume	45
Issue number	3
DOIs	https://doi.org/10.1002/jmri.25389
State	Published - Mar 1 2017

Bibliographical note

Funding Information:
This work was supported by a National Institutes of Health (NIH) Director's Early Independence Award, a grant from the National Institute of General Medical Science of the National Institutes of Health, a NIH Ruth L. Kirschstein fellowship, and grant from the National Center for Research Resources (NCRR), funded by the Office of the Director, National Institutes of Health and supported by the NIH Roadmap for Medical Research. The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding sources. The authors have no competing interests to disclose.

Publisher Copyright:
© 2016 International Society for Magnetic Resonance in Medicine

Keywords

DENSE
breathholds
navigator efficiency
respiratory navigator
signal-to-noise ratio
strain

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1002/jmri.25389

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Hamlet, S. M., Haggerty, C. M., Suever, J. D., Wehner, G. J., Andres, K. N., Powell, D. K., Zhong, X., & Fornwalt, B. K. (2017). Optimal configuration of respiratory navigator gating for the quantification of left ventricular strain using spiral cine displacement encoding with stimulated echoes (DENSE) MRI. Journal of Magnetic Resonance Imaging, 45(3), 786-794. https://doi.org/10.1002/jmri.25389

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title = "Optimal configuration of respiratory navigator gating for the quantification of left ventricular strain using spiral cine displacement encoding with stimulated echoes (DENSE) MRI",

abstract = "Purpose: To determine the optimal respiratory navigator gating configuration for the quantification of left ventricular strain using spiral cine displacement encoding with stimulated echoes (DENSE) MRI. Materials and Methods: Two-dimensional spiral cine DENSE was performed on a 3 Tesla MRI using two single-navigator configurations (retrospective, prospective) and a combined “dual-navigator” configuration in 10 healthy adults and 20 healthy children. The adults also underwent breathhold DENSE as a reference standard for comparisons. Peak left ventricular strains, signal-to-noise ratio (SNR), and navigator efficiency were compared. Subjects also underwent dual-navigator gating with and without visual feedback to determine the effect on navigator efficiency. Results: There were no differences in circumferential, radial, and longitudinal strains between navigator-gated and breathhold DENSE (P = 0.09–0.95) (as confidence intervals, retrospective: [-1.0%–1.1%], [-7.4%–2.0%], [-1.0%–1.2%]; prospective: [-0.6%–2.7%], [-2.8%–8.3%], [-0.3%–2.9%]; dual: [-1.6%–0.5%], [-8.3%–3.2%], [-0.8%–1.9%], respectively). The dual configuration maintained SNR compared with breathhold acquisitions (16 versus 18, P = 0.06). SNR for the prospective configuration was lower than for the dual navigator in adults (P = 0.004) and children (P < 0.001). Navigator efficiency was higher (P < 0.001) for both retrospective (54%) and prospective (56%) configurations compared with the dual configuration (35%). Visual feedback improved the dual configuration navigator efficiency to 55% (P < 0.001). Conclusion: When quantifying left ventricular strains using spiral cine DENSE MRI, a dual navigator configuration results in the highest SNR in adults and children. In adults, a retrospective configuration has good navigator efficiency without a substantial drop in SNR. Prospective gating should be avoided because it has the lowest SNR. Visual feedback represents an effective option to maintain navigator efficiency while using a dual navigator configuration. Level of Evidence: 2. J. Magn. Reson. Imaging 2017;45:786–794.",

keywords = "DENSE, breathholds, navigator efficiency, respiratory navigator, signal-to-noise ratio, strain",

author = "Hamlet, {Sean M.} and Haggerty, {Christopher M.} and Suever, {Jonathan D.} and Wehner, {Gregory J.} and Andres, {Kristin N.} and Powell, {David K.} and Xiaodong Zhong and Fornwalt, {Brandon K.}",

note = "Funding Information: This work was supported by a National Institutes of Health (NIH) Director's Early Independence Award, a grant from the National Institute of General Medical Science of the National Institutes of Health, a NIH Ruth L. Kirschstein fellowship, and grant from the National Center for Research Resources (NCRR), funded by the Office of the Director, National Institutes of Health and supported by the NIH Roadmap for Medical Research. The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding sources. The authors have no competing interests to disclose. Publisher Copyright: {\textcopyright} 2016 International Society for Magnetic Resonance in Medicine",

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Hamlet, SM, Haggerty, CM, Suever, JD, Wehner, GJ, Andres, KN, Powell, DK, Zhong, X & Fornwalt, BK 2017, 'Optimal configuration of respiratory navigator gating for the quantification of left ventricular strain using spiral cine displacement encoding with stimulated echoes (DENSE) MRI', Journal of Magnetic Resonance Imaging, vol. 45, no. 3, pp. 786-794. https://doi.org/10.1002/jmri.25389

Optimal configuration of respiratory navigator gating for the quantification of left ventricular strain using spiral cine displacement encoding with stimulated echoes (DENSE) MRI. / Hamlet, Sean M.; Haggerty, Christopher M.; Suever, Jonathan D. et al.
In: Journal of Magnetic Resonance Imaging, Vol. 45, No. 3, 01.03.2017, p. 786-794.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Optimal configuration of respiratory navigator gating for the quantification of left ventricular strain using spiral cine displacement encoding with stimulated echoes (DENSE) MRI

AU - Hamlet, Sean M.

AU - Haggerty, Christopher M.

AU - Suever, Jonathan D.

AU - Wehner, Gregory J.

AU - Andres, Kristin N.

AU - Powell, David K.

AU - Zhong, Xiaodong

AU - Fornwalt, Brandon K.

N1 - Funding Information: This work was supported by a National Institutes of Health (NIH) Director's Early Independence Award, a grant from the National Institute of General Medical Science of the National Institutes of Health, a NIH Ruth L. Kirschstein fellowship, and grant from the National Center for Research Resources (NCRR), funded by the Office of the Director, National Institutes of Health and supported by the NIH Roadmap for Medical Research. The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding sources. The authors have no competing interests to disclose. Publisher Copyright: © 2016 International Society for Magnetic Resonance in Medicine

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Purpose: To determine the optimal respiratory navigator gating configuration for the quantification of left ventricular strain using spiral cine displacement encoding with stimulated echoes (DENSE) MRI. Materials and Methods: Two-dimensional spiral cine DENSE was performed on a 3 Tesla MRI using two single-navigator configurations (retrospective, prospective) and a combined “dual-navigator” configuration in 10 healthy adults and 20 healthy children. The adults also underwent breathhold DENSE as a reference standard for comparisons. Peak left ventricular strains, signal-to-noise ratio (SNR), and navigator efficiency were compared. Subjects also underwent dual-navigator gating with and without visual feedback to determine the effect on navigator efficiency. Results: There were no differences in circumferential, radial, and longitudinal strains between navigator-gated and breathhold DENSE (P = 0.09–0.95) (as confidence intervals, retrospective: [-1.0%–1.1%], [-7.4%–2.0%], [-1.0%–1.2%]; prospective: [-0.6%–2.7%], [-2.8%–8.3%], [-0.3%–2.9%]; dual: [-1.6%–0.5%], [-8.3%–3.2%], [-0.8%–1.9%], respectively). The dual configuration maintained SNR compared with breathhold acquisitions (16 versus 18, P = 0.06). SNR for the prospective configuration was lower than for the dual navigator in adults (P = 0.004) and children (P < 0.001). Navigator efficiency was higher (P < 0.001) for both retrospective (54%) and prospective (56%) configurations compared with the dual configuration (35%). Visual feedback improved the dual configuration navigator efficiency to 55% (P < 0.001). Conclusion: When quantifying left ventricular strains using spiral cine DENSE MRI, a dual navigator configuration results in the highest SNR in adults and children. In adults, a retrospective configuration has good navigator efficiency without a substantial drop in SNR. Prospective gating should be avoided because it has the lowest SNR. Visual feedback represents an effective option to maintain navigator efficiency while using a dual navigator configuration. Level of Evidence: 2. J. Magn. Reson. Imaging 2017;45:786–794.

AB - Purpose: To determine the optimal respiratory navigator gating configuration for the quantification of left ventricular strain using spiral cine displacement encoding with stimulated echoes (DENSE) MRI. Materials and Methods: Two-dimensional spiral cine DENSE was performed on a 3 Tesla MRI using two single-navigator configurations (retrospective, prospective) and a combined “dual-navigator” configuration in 10 healthy adults and 20 healthy children. The adults also underwent breathhold DENSE as a reference standard for comparisons. Peak left ventricular strains, signal-to-noise ratio (SNR), and navigator efficiency were compared. Subjects also underwent dual-navigator gating with and without visual feedback to determine the effect on navigator efficiency. Results: There were no differences in circumferential, radial, and longitudinal strains between navigator-gated and breathhold DENSE (P = 0.09–0.95) (as confidence intervals, retrospective: [-1.0%–1.1%], [-7.4%–2.0%], [-1.0%–1.2%]; prospective: [-0.6%–2.7%], [-2.8%–8.3%], [-0.3%–2.9%]; dual: [-1.6%–0.5%], [-8.3%–3.2%], [-0.8%–1.9%], respectively). The dual configuration maintained SNR compared with breathhold acquisitions (16 versus 18, P = 0.06). SNR for the prospective configuration was lower than for the dual navigator in adults (P = 0.004) and children (P < 0.001). Navigator efficiency was higher (P < 0.001) for both retrospective (54%) and prospective (56%) configurations compared with the dual configuration (35%). Visual feedback improved the dual configuration navigator efficiency to 55% (P < 0.001). Conclusion: When quantifying left ventricular strains using spiral cine DENSE MRI, a dual navigator configuration results in the highest SNR in adults and children. In adults, a retrospective configuration has good navigator efficiency without a substantial drop in SNR. Prospective gating should be avoided because it has the lowest SNR. Visual feedback represents an effective option to maintain navigator efficiency while using a dual navigator configuration. Level of Evidence: 2. J. Magn. Reson. Imaging 2017;45:786–794.

KW - DENSE

KW - breathholds

KW - navigator efficiency

KW - respiratory navigator

KW - signal-to-noise ratio

KW - strain

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Optimal configuration of respiratory navigator gating for the quantification of left ventricular strain using spiral cine displacement encoding with stimulated echoes (DENSE) MRI

Abstract

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Keywords

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