Abstract
Extinction coefficient (ε) is a critical parameter for quantification of oxy-, deoxy-, and total-hemoglobin concentrations (Δ[HbO2], Δ[Hb], Δ[tHb]) from optical measurements of Near-infrared spectroscopy (NIRS). There are several different ε data sets which were frequently used in NIRS quantification. A previous study reported that even a small variation in ε could cause a significant difference in hemodynamic measurements. Apparently the selection of an optimal ε data set is important for NIRS. We conducted oxygen-state-varied and blood-concentration-varied model experiments with 57 human blood samples to mimic tissue hemodynamic variations. Seven reported ε data sets were evaluated by comparisons between quantifications and assumed values. We found that the Moaveni et al (1970)’ ε data set was the optimal one, the NIRS quantification varied significantly among different ε data sets and parameter Δ[tHb] was most sensitive to ε data sets selection.
Original language | English |
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Article number | #303715 |
Pages (from-to) | 5151-5159 |
Number of pages | 9 |
Journal | Biomedical Optics Express |
Volume | 8 |
Issue number | 11 |
DOIs | |
State | Published - Nov 1 2017 |
Bibliographical note
Publisher Copyright:© 2017 Optical Society of America.
ASJC Scopus subject areas
- Biotechnology
- Atomic and Molecular Physics, and Optics