Optimal self-referenced sensing using long - And short - range surface plasmons

J. T. Hastings, J. Guo, P. D. Keathley, P. B. Kumaresh, Y. Wei, S. Law, L. G. Bachas

Research output: Contribution to journalArticlepeer-review

58 Scopus citations


Dual-mode surface-plasmon resonance (SPR) sensors use both long- and short- range surface plasmon waves to differentiate surface binding interactions from interfering bulk effects. We have optimized the design of these sensors for minimum surface limit of detection (LOD) using a Cramer-Rao lower bound for spectral shift estimation. Despite trade-offs between resonance width, minimum reflectivity, and sensitivity for the two modes, a range of reasonable design parameters provides nearly optimal performance. Experimental verification using biotin-streptavidin binding as a model system reveals that sensitivity and LOD for dual-mode sensors remains competitive with single-mode sensors while compensating for bulk effects.

Original languageEnglish
Pages (from-to)17661-17672
Number of pages12
JournalOptics Express
Issue number26
StatePublished - Dec 24 2007

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics


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