TY - JOUR
T1 - Optimization of a digital health intervention to enhance well-being among adolescent and young adult cancer survivors
T2 - Design and methods of the EMPOWER full factorial trial
AU - Salsman, John M.
AU - Murphy, Karly M.
AU - Addington, Elizabeth L.
AU - Tooze, Janet A.
AU - McLouth, Laurie E.
AU - Yang, Dershung
AU - Sanford, Stacy
AU - Wagner, Lynne
AU - Bunch, Stephanie C.
AU - Rosenberg, Abby R.
AU - Valle, Carmina G.
AU - Zebrack, Brad
AU - Howard, Dianna
AU - Roth, Michael
AU - Moskowitz, Judith T.
N1 - Publisher Copyright:
© 2024 Elsevier Inc.
PY - 2025/2
Y1 - 2025/2
N2 - Adolescent and young adult cancer survivors (AYAs) experience clinically significant distress and have limited access to supportive care services. Interventions to enhance psychological well-being have improved positive affect and reduced depression in clinical and healthy populations and have not been routinely tested in AYA survivors. We are optimizing a web-based positive skills intervention for AYA cancer survivors called Enhancing Management of Psychological Outcomes With Emotion Regulation (EMPOWER) by: (1) determining which intervention components have the strongest effects on well-being and (2) identifying demographic and individual difference variables that mediate and moderate EMPOWER's efficacy. EMPOWER is a five-session online intervention that teaches behavioral and cognitive skills for increasing psychological well-being. Guided by the Multiphase Optimization Strategy (MOST), we assign two levels (yes, no) to each of five intervention components (positive events, capitalizing, & gratitude; mindfulness; positive reappraisal; personal strengths & goal-setting; acts of kindness), allowing us to evaluate the effects of individual and combined intervention components on positive affect in a full factorial design. Post-treatment AYA cancer survivors (N = 352) are recruited from participating NCI-designated comprehensive cancer centers and randomized to one of 32 experimental conditions. Our primary outcome is positive affect; potential mediating and moderating variables include coping self-efficacy and emotional support, respectively. Upon trial completion, we will have an optimized, digital health intervention to enhance psychological well-being among AYA cancer survivors. EMPOWER will be scalable and primed for a large, multi-site trial among AYAs who would otherwise not have access to supportive care interventions to manage distress and enhance well-being.
AB - Adolescent and young adult cancer survivors (AYAs) experience clinically significant distress and have limited access to supportive care services. Interventions to enhance psychological well-being have improved positive affect and reduced depression in clinical and healthy populations and have not been routinely tested in AYA survivors. We are optimizing a web-based positive skills intervention for AYA cancer survivors called Enhancing Management of Psychological Outcomes With Emotion Regulation (EMPOWER) by: (1) determining which intervention components have the strongest effects on well-being and (2) identifying demographic and individual difference variables that mediate and moderate EMPOWER's efficacy. EMPOWER is a five-session online intervention that teaches behavioral and cognitive skills for increasing psychological well-being. Guided by the Multiphase Optimization Strategy (MOST), we assign two levels (yes, no) to each of five intervention components (positive events, capitalizing, & gratitude; mindfulness; positive reappraisal; personal strengths & goal-setting; acts of kindness), allowing us to evaluate the effects of individual and combined intervention components on positive affect in a full factorial design. Post-treatment AYA cancer survivors (N = 352) are recruited from participating NCI-designated comprehensive cancer centers and randomized to one of 32 experimental conditions. Our primary outcome is positive affect; potential mediating and moderating variables include coping self-efficacy and emotional support, respectively. Upon trial completion, we will have an optimized, digital health intervention to enhance psychological well-being among AYA cancer survivors. EMPOWER will be scalable and primed for a large, multi-site trial among AYAs who would otherwise not have access to supportive care interventions to manage distress and enhance well-being.
KW - Adolescent & young adult
KW - Cancer
KW - Factorial design
KW - Psychosocial
KW - Well-being
UR - http://www.scopus.com/inward/record.url?scp=85213057984&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85213057984&partnerID=8YFLogxK
U2 - 10.1016/j.cct.2024.107783
DO - 10.1016/j.cct.2024.107783
M3 - Article
C2 - 39710338
AN - SCOPUS:85213057984
SN - 1551-7144
VL - 149
JO - Contemporary Clinical Trials
JF - Contemporary Clinical Trials
M1 - 107783
ER -
