Oral contraceptive use and cervical intraepithelial neoplasia

Ann L. Coker, Margaret F. McCann, Barbara S. Hulka, Leslie A. Walton

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


To explore the somewhat controversial relationship between oral contraceptives and and-invasive cervical cancer, 103 cases of biopsy-confirmed cervical intraepithelial neoplasia (CIN) II or CIN III were compared with 258 controls who had normal cervical cytology. Cases were slightly less likely than controls to have ever used oral contraceptives; the odds ratio, controlling for age, socioeconomic status, barrier method use, smoking history, age at first sexual intercourse, number of sex partners, current marital status, and number of Pap smears, was 0.7 (95% CI 0.3-1.6). Recency, latency, duration, and age at first oral contraceptive use were evaluted and in no instance was oral contraceptive use positively associated with CIN. This study adds to the body of knowledge that oral contraceptives are not associated with pre-invasive cervical cancer. Further, if oral contraceptive users continue to be regularly screened, their risk of developing the more invasive lesions should be very low.

Original languageEnglish
Pages (from-to)1111-1118
Number of pages8
JournalJournal of Clinical Epidemiology
Issue number10
StatePublished - Oct 1992

Bibliographical note

Funding Information:
Acknowledgements-This work was conducted within the Department of Epidemiology at the University of North Carolina, Chapel Hill and was supported by grants from the National Cancer Insititute, 5-R03 CA46437-02 and 5-T32-CAO9330.


  • Cervix neoplasms
  • Contraceptive agents
  • Epidemiology
  • Risk
  • Sex behavior
  • Smoking

ASJC Scopus subject areas

  • Epidemiology


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