Oral contraceptive use and cervical intraepithelial neoplasia

Ann L. Coker; Margaret F. McCann; Barbara S. Hulka; Leslie A. Walton

doi:10.1016/0895-4356(92)90151-C

Oral contraceptive use and cervical intraepithelial neoplasia

Ann L. Coker
, Margaret F. McCann
, Barbara S. Hulka
, Leslie A. Walton

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

To explore the somewhat controversial relationship between oral contraceptives and and-invasive cervical cancer, 103 cases of biopsy-confirmed cervical intraepithelial neoplasia (CIN) II or CIN III were compared with 258 controls who had normal cervical cytology. Cases were slightly less likely than controls to have ever used oral contraceptives; the odds ratio, controlling for age, socioeconomic status, barrier method use, smoking history, age at first sexual intercourse, number of sex partners, current marital status, and number of Pap smears, was 0.7 (95% CI 0.3-1.6). Recency, latency, duration, and age at first oral contraceptive use were evaluted and in no instance was oral contraceptive use positively associated with CIN. This study adds to the body of knowledge that oral contraceptives are not associated with pre-invasive cervical cancer. Further, if oral contraceptive users continue to be regularly screened, their risk of developing the more invasive lesions should be very low.

Original language	English
Pages (from-to)	1111-1118
Number of pages	8
Journal	Journal of Clinical Epidemiology
Volume	45
Issue number	10
DOIs	https://doi.org/10.1016/0895-4356(92)90151-C
State	Published - Oct 1992

Bibliographical note

Funding Information:
Acknowledgements-This work was conducted within the Department of Epidemiology at the University of North Carolina, Chapel Hill and was supported by grants from the National Cancer Insititute, 5-R03 CA46437-02 and 5-T32-CAO9330.

Funding

Acknowledgements-This work was conducted within the Department of Epidemiology at the University of North Carolina, Chapel Hill and was supported by grants from the National Cancer Insititute, 5-R03 CA46437-02 and 5-T32-CAO9330.

Funders	Funder number
National Cancer Insititute	5-R03 CA46437-02, 5-T32-CAO9330
National Childhood Cancer Registry – National Cancer Institute	T32CA009330
University of North Carolina and North Carolina State University

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cervix neoplasms
Contraceptive agents
Epidemiology
Risk
Sex behavior
Smoking

ASJC Scopus subject areas

Epidemiology

Access to Document

10.1016/0895-4356(92)90151-C

Cite this

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title = "Oral contraceptive use and cervical intraepithelial neoplasia",

abstract = "To explore the somewhat controversial relationship between oral contraceptives and and-invasive cervical cancer, 103 cases of biopsy-confirmed cervical intraepithelial neoplasia (CIN) II or CIN III were compared with 258 controls who had normal cervical cytology. Cases were slightly less likely than controls to have ever used oral contraceptives; the odds ratio, controlling for age, socioeconomic status, barrier method use, smoking history, age at first sexual intercourse, number of sex partners, current marital status, and number of Pap smears, was 0.7 (95\% CI 0.3-1.6). Recency, latency, duration, and age at first oral contraceptive use were evaluted and in no instance was oral contraceptive use positively associated with CIN. This study adds to the body of knowledge that oral contraceptives are not associated with pre-invasive cervical cancer. Further, if oral contraceptive users continue to be regularly screened, their risk of developing the more invasive lesions should be very low.",

keywords = "Cervix neoplasms, Contraceptive agents, Epidemiology, Risk, Sex behavior, Smoking",

author = "Coker, \{Ann L.\} and McCann, \{Margaret F.\} and Hulka, \{Barbara S.\} and Walton, \{Leslie A.\}",

note = "Funding Information: Acknowledgements-This work was conducted within the Department of Epidemiology at the University of North Carolina, Chapel Hill and was supported by grants from the National Cancer Insititute, 5-R03 CA46437-02 and 5-T32-CAO9330.",

year = "1992",

month = oct,

doi = "10.1016/0895-4356(92)90151-C",

language = "English",

volume = "45",

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AU - Coker, Ann L.

AU - McCann, Margaret F.

AU - Hulka, Barbara S.

AU - Walton, Leslie A.

N1 - Funding Information: Acknowledgements-This work was conducted within the Department of Epidemiology at the University of North Carolina, Chapel Hill and was supported by grants from the National Cancer Insititute, 5-R03 CA46437-02 and 5-T32-CAO9330.

PY - 1992/10

Y1 - 1992/10

N2 - To explore the somewhat controversial relationship between oral contraceptives and and-invasive cervical cancer, 103 cases of biopsy-confirmed cervical intraepithelial neoplasia (CIN) II or CIN III were compared with 258 controls who had normal cervical cytology. Cases were slightly less likely than controls to have ever used oral contraceptives; the odds ratio, controlling for age, socioeconomic status, barrier method use, smoking history, age at first sexual intercourse, number of sex partners, current marital status, and number of Pap smears, was 0.7 (95% CI 0.3-1.6). Recency, latency, duration, and age at first oral contraceptive use were evaluted and in no instance was oral contraceptive use positively associated with CIN. This study adds to the body of knowledge that oral contraceptives are not associated with pre-invasive cervical cancer. Further, if oral contraceptive users continue to be regularly screened, their risk of developing the more invasive lesions should be very low.

AB - To explore the somewhat controversial relationship between oral contraceptives and and-invasive cervical cancer, 103 cases of biopsy-confirmed cervical intraepithelial neoplasia (CIN) II or CIN III were compared with 258 controls who had normal cervical cytology. Cases were slightly less likely than controls to have ever used oral contraceptives; the odds ratio, controlling for age, socioeconomic status, barrier method use, smoking history, age at first sexual intercourse, number of sex partners, current marital status, and number of Pap smears, was 0.7 (95% CI 0.3-1.6). Recency, latency, duration, and age at first oral contraceptive use were evaluted and in no instance was oral contraceptive use positively associated with CIN. This study adds to the body of knowledge that oral contraceptives are not associated with pre-invasive cervical cancer. Further, if oral contraceptive users continue to be regularly screened, their risk of developing the more invasive lesions should be very low.

KW - Cervix neoplasms

KW - Contraceptive agents

KW - Epidemiology

KW - Risk

KW - Sex behavior

KW - Smoking

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SN - 0895-4356

VL - 45

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JF - Journal of Clinical Epidemiology

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ER -

Oral contraceptive use and cervical intraepithelial neoplasia

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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