Oral fluids that detect cardiovascular disease biomarkers

Joseph D. Foley; J. Darrell Sneed; Steven R. Steinhubl; Justin Kolasa; Jeffrey L. Ebersole; Yushun Lin; Richard J. Kryscio; John T. McDevitt; Charles L. Campbell; Craig S. Miller

doi:10.1016/j.oooo.2012.03.003

Oral fluids that detect cardiovascular disease biomarkers

Joseph D. Foley, J. Darrell Sneed, Steven R. Steinhubl, Justin Kolasa, Jeffrey L. Ebersole, Yushun Lin, Richard J. Kryscio, John T. McDevitt, Charles L. Campbell, Craig S. Miller

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Objective: The aim of this study was to determine the utility of oral fluids for assessment of coronary and cardiovascular (CV) health. Study Design: Twenty-nine patients with preexisting CV disease underwent an invasive cardiac procedure (alcohol septal ablation or percutaneous coronary intervention) and provided unstimulated whole saliva (UWS), sublingual swabs (LS), gingival swabs (GS) and serum at 0, 8, 16, 24, and 48 hours. Concentrations of 13 relevant biomarkers were determined and correlated with levels in serum and the oral fluids. Results: Concentrations of the majority of biomarkers were higher in UWS than in LS and GS. Coronary and CV disease biomarkers in UWS correlated better with serum than with LS and GS based on group status and measures of time effect. Seven biomarkers demonstrated time effect changes consistent with serum biomarkers, including C-reactive protein and troponin I. Conclusions: Changes in serum biomarker profiles are reflected in oral fluids suggesting that oral fluid biomarkers could aid in the assessment of cardiac ischemia/necrosis.

Original language	English
Pages (from-to)	207-214
Number of pages	8
Journal	Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume	114
Issue number	2
DOIs	https://doi.org/10.1016/j.oooo.2012.03.003
State	Published - Aug 2012

Bibliographical note

Funding Information:
Supported by grants from the National Institutes of Health ( P20 RR020145 , U01 DE017793 , and M01-RR02602 ), the University of Kentucky General Clinical Research Core , and in part by Clinical Translational Science Award UL1RR033173 .

ASJC Scopus subject areas

Surgery
Oral Surgery
Pathology and Forensic Medicine
Dentistry (miscellaneous)
Radiology Nuclear Medicine and imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.oooo.2012.03.003

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title = "Oral fluids that detect cardiovascular disease biomarkers",

abstract = "Objective: The aim of this study was to determine the utility of oral fluids for assessment of coronary and cardiovascular (CV) health. Study Design: Twenty-nine patients with preexisting CV disease underwent an invasive cardiac procedure (alcohol septal ablation or percutaneous coronary intervention) and provided unstimulated whole saliva (UWS), sublingual swabs (LS), gingival swabs (GS) and serum at 0, 8, 16, 24, and 48 hours. Concentrations of 13 relevant biomarkers were determined and correlated with levels in serum and the oral fluids. Results: Concentrations of the majority of biomarkers were higher in UWS than in LS and GS. Coronary and CV disease biomarkers in UWS correlated better with serum than with LS and GS based on group status and measures of time effect. Seven biomarkers demonstrated time effect changes consistent with serum biomarkers, including C-reactive protein and troponin I. Conclusions: Changes in serum biomarker profiles are reflected in oral fluids suggesting that oral fluid biomarkers could aid in the assessment of cardiac ischemia/necrosis.",

author = "Foley, {Joseph D.} and Sneed, {J. Darrell} and Steinhubl, {Steven R.} and Justin Kolasa and Ebersole, {Jeffrey L.} and Yushun Lin and Kryscio, {Richard J.} and McDevitt, {John T.} and Campbell, {Charles L.} and Miller, {Craig S.}",

note = "Funding Information: Supported by grants from the National Institutes of Health ( P20 RR020145 , U01 DE017793 , and M01-RR02602 ), the University of Kentucky General Clinical Research Core , and in part by Clinical Translational Science Award UL1RR033173 . ",

year = "2012",

month = aug,

doi = "10.1016/j.oooo.2012.03.003",

language = "English",

volume = "114",

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T1 - Oral fluids that detect cardiovascular disease biomarkers

AU - Foley, Joseph D.

AU - Sneed, J. Darrell

AU - Steinhubl, Steven R.

AU - Kolasa, Justin

AU - Ebersole, Jeffrey L.

AU - Lin, Yushun

AU - Kryscio, Richard J.

AU - McDevitt, John T.

AU - Campbell, Charles L.

AU - Miller, Craig S.

N1 - Funding Information: Supported by grants from the National Institutes of Health ( P20 RR020145 , U01 DE017793 , and M01-RR02602 ), the University of Kentucky General Clinical Research Core , and in part by Clinical Translational Science Award UL1RR033173 .

PY - 2012/8

Y1 - 2012/8

N2 - Objective: The aim of this study was to determine the utility of oral fluids for assessment of coronary and cardiovascular (CV) health. Study Design: Twenty-nine patients with preexisting CV disease underwent an invasive cardiac procedure (alcohol septal ablation or percutaneous coronary intervention) and provided unstimulated whole saliva (UWS), sublingual swabs (LS), gingival swabs (GS) and serum at 0, 8, 16, 24, and 48 hours. Concentrations of 13 relevant biomarkers were determined and correlated with levels in serum and the oral fluids. Results: Concentrations of the majority of biomarkers were higher in UWS than in LS and GS. Coronary and CV disease biomarkers in UWS correlated better with serum than with LS and GS based on group status and measures of time effect. Seven biomarkers demonstrated time effect changes consistent with serum biomarkers, including C-reactive protein and troponin I. Conclusions: Changes in serum biomarker profiles are reflected in oral fluids suggesting that oral fluid biomarkers could aid in the assessment of cardiac ischemia/necrosis.

AB - Objective: The aim of this study was to determine the utility of oral fluids for assessment of coronary and cardiovascular (CV) health. Study Design: Twenty-nine patients with preexisting CV disease underwent an invasive cardiac procedure (alcohol septal ablation or percutaneous coronary intervention) and provided unstimulated whole saliva (UWS), sublingual swabs (LS), gingival swabs (GS) and serum at 0, 8, 16, 24, and 48 hours. Concentrations of 13 relevant biomarkers were determined and correlated with levels in serum and the oral fluids. Results: Concentrations of the majority of biomarkers were higher in UWS than in LS and GS. Coronary and CV disease biomarkers in UWS correlated better with serum than with LS and GS based on group status and measures of time effect. Seven biomarkers demonstrated time effect changes consistent with serum biomarkers, including C-reactive protein and troponin I. Conclusions: Changes in serum biomarker profiles are reflected in oral fluids suggesting that oral fluid biomarkers could aid in the assessment of cardiac ischemia/necrosis.

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Oral fluids that detect cardiovascular disease biomarkers

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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