Oral fluids that detect cardiovascular disease biomarkers

Joseph D. Foley, J. Darrell Sneed, Steven R. Steinhubl, Justin Kolasa, Jeffrey L. Ebersole, Yushun Lin, Richard J. Kryscio, John T. McDevitt, Charles L. Campbell, Craig S. Miller

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Objective: The aim of this study was to determine the utility of oral fluids for assessment of coronary and cardiovascular (CV) health. Study Design: Twenty-nine patients with preexisting CV disease underwent an invasive cardiac procedure (alcohol septal ablation or percutaneous coronary intervention) and provided unstimulated whole saliva (UWS), sublingual swabs (LS), gingival swabs (GS) and serum at 0, 8, 16, 24, and 48 hours. Concentrations of 13 relevant biomarkers were determined and correlated with levels in serum and the oral fluids. Results: Concentrations of the majority of biomarkers were higher in UWS than in LS and GS. Coronary and CV disease biomarkers in UWS correlated better with serum than with LS and GS based on group status and measures of time effect. Seven biomarkers demonstrated time effect changes consistent with serum biomarkers, including C-reactive protein and troponin I. Conclusions: Changes in serum biomarker profiles are reflected in oral fluids suggesting that oral fluid biomarkers could aid in the assessment of cardiac ischemia/necrosis.

Original languageEnglish
Pages (from-to)207-214
Number of pages8
JournalOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Issue number2
StatePublished - Aug 2012

Bibliographical note

Funding Information:
Whole saliva is a unique fluid derived from the major and minor salivary glands. Its composition of organic and inorganic molecules, exfoliated cells, and microbes makes it a rich resource for the assessment of health. Its diagnostic capacity has been documented for nearly 40 years 1 and reviewed in many papers. 2-6 Boosted by recent funding from the National Institutes of Health, proteomic studies have revealed more than 1,000 proteins and 19,000 unique peptide sequences in saliva. 7,8 Yet, clinical utility for salivary diagnostics regarding the assessment of systemic disease has remained elusive. 9-14

Funding Information:
Supported by grants from the National Institutes of Health ( P20 RR020145 , U01 DE017793 , and M01-RR02602 ), the University of Kentucky General Clinical Research Core , and in part by Clinical Translational Science Award UL1RR033173 .

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Pathology and Forensic Medicine
  • Dentistry (miscellaneous)
  • Radiology Nuclear Medicine and imaging


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