TY - JOUR
T1 - Oral phenytoin loading in adults
T2 - Rapid achievement of therapeutic plasma levels
AU - Record, Kenneth E.
AU - Rapp, Robert P.
AU - Young, A. Byron
AU - Kostenbauder, Harry B.
PY - 1979/3
Y1 - 1979/3
N2 - Oral loading doses of phenytoin were estimated from a simplified pharmacokinetic model. Twenty patients were administered a calculated average dose of 19.1 mg per kilogram of phenytoin divided into two to four increments given over 3 to 21 hours (10.55 ± 4.74, mean ± SD). Plasma samples drawn 2 to 22 hours (10.75 ± 4.32, mean ± SD) after completion of the loading dose resulted in therapeutic levels ranging from 8.1 to 18.0 μg per milliliter (11.42–11.37 ± 2.41, mean ± SD). Thus, this regimen in which no increment of the loading dose exceeds 600 mg is sufficient to achieve and maintain therapeutic plasma concentrations 18 to 24 hours after initiation of the loading dose.
AB - Oral loading doses of phenytoin were estimated from a simplified pharmacokinetic model. Twenty patients were administered a calculated average dose of 19.1 mg per kilogram of phenytoin divided into two to four increments given over 3 to 21 hours (10.55 ± 4.74, mean ± SD). Plasma samples drawn 2 to 22 hours (10.75 ± 4.32, mean ± SD) after completion of the loading dose resulted in therapeutic levels ranging from 8.1 to 18.0 μg per milliliter (11.42–11.37 ± 2.41, mean ± SD). Thus, this regimen in which no increment of the loading dose exceeds 600 mg is sufficient to achieve and maintain therapeutic plasma concentrations 18 to 24 hours after initiation of the loading dose.
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U2 - 10.1002/ana.410050309
DO - 10.1002/ana.410050309
M3 - Article
C2 - 443759
AN - SCOPUS:0018390483
SN - 0364-5134
VL - 5
SP - 268
EP - 270
JO - Annals of Neurology
JF - Annals of Neurology
IS - 3
ER -