Oral tolerance therapy in autoimmune disease

S. D. Hurst, S. M. Nicholson, T. A. Barrett

Research output: Contribution to journalShort surveypeer-review

2 Scopus citations


Results from a recent clinical trial have suggested that the feeding of autoantigenic proteins may be an effective therapy for autoimmune diseases. This treatment, called oral tolerance therapy, proposes to inhibit aberrant immune responses by producing immune 'acceptance' or tolerance to target tissue proteins. Because of the innovative nature of this approach, interest has been focused on the regulatory mechanisms that produce the state of oral tolerance. In this review, we address the models of oral tolerance and suggest that this state may involve unique regulatory mechanisms based on the amount of fed protein antigen.

Original languageEnglish
Pages (from-to)981-985
Number of pages5
JournalCurrent Opinion in Gastroenterology
Issue number6
StatePublished - 1993

ASJC Scopus subject areas

  • Gastroenterology


Dive into the research topics of 'Oral tolerance therapy in autoimmune disease'. Together they form a unique fingerprint.

Cite this