TY - JOUR
T1 - Oral tolerance therapy in autoimmune disease
AU - Hurst, S. D.
AU - Nicholson, S. M.
AU - Barrett, T. A.
PY - 1993
Y1 - 1993
N2 - Results from a recent clinical trial have suggested that the feeding of autoantigenic proteins may be an effective therapy for autoimmune diseases. This treatment, called oral tolerance therapy, proposes to inhibit aberrant immune responses by producing immune 'acceptance' or tolerance to target tissue proteins. Because of the innovative nature of this approach, interest has been focused on the regulatory mechanisms that produce the state of oral tolerance. In this review, we address the models of oral tolerance and suggest that this state may involve unique regulatory mechanisms based on the amount of fed protein antigen.
AB - Results from a recent clinical trial have suggested that the feeding of autoantigenic proteins may be an effective therapy for autoimmune diseases. This treatment, called oral tolerance therapy, proposes to inhibit aberrant immune responses by producing immune 'acceptance' or tolerance to target tissue proteins. Because of the innovative nature of this approach, interest has been focused on the regulatory mechanisms that produce the state of oral tolerance. In this review, we address the models of oral tolerance and suggest that this state may involve unique regulatory mechanisms based on the amount of fed protein antigen.
UR - http://www.scopus.com/inward/record.url?scp=0027487406&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027487406&partnerID=8YFLogxK
U2 - 10.1097/00001574-199309060-00014
DO - 10.1097/00001574-199309060-00014
M3 - Short survey
AN - SCOPUS:0027487406
SN - 0267-1379
VL - 9
SP - 981
EP - 985
JO - Current Opinion in Gastroenterology
JF - Current Opinion in Gastroenterology
IS - 6
ER -