Oral vaccination with alginate microsphere systems

T. L. Bowersock, H. HogenEsch, M. Suckow, R. E. Porter, R. Jackson, H. Park, K. Park

Research output: Contribution to journalArticlepeer-review

90 Scopus citations


Oral vaccination is a simple, efficient way of inducing immunity at mucosal surfaces. The slow development of oral vaccines has been mainly due to the lack of suitable delivery systems. We have used hydrogel microspheres to deliver various vaccines to several animal species by oral administration. Oral delivery of vaccines using alginate microspheres elicited the production of secretory IgA (sIgA) at the mucosal surfaces in mice, rabbits, and cattle. Oral vaccination of chicken resulted in an increased delayed type hypersensitivity, a cell-mediated immune response, indicating a positive response to the vaccine. Our studies have clearly shown that alginate microspheres are effective for the oral administration of vaccines.

Original languageEnglish
Pages (from-to)209-220
Number of pages12
JournalJournal of Controlled Release
Issue number2-3
StatePublished - May 1996


  • Alginate microsphere
  • Mucosal immunity
  • Oral vaccination
  • Secretory IgA

ASJC Scopus subject areas

  • Pharmaceutical Science


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