OralCandida albicans in bone marrow transplant patients given chlorhexidine rinses: Occurrence and susceptibilities to the agent

Jennifer M. Thurmond, Albert T. Brown, Robert E. Sims, Gerald A. Ferretti, Ted P. Raybould, Thomas T. Lillich, P. Jean Henslee

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

The tongue and buccal mucosa of 26 bone marrow transplant recipients given three 0.12% chlorhexidine digluconate (CHX) oral rinses daily for 8 weeks were sampled weekly for oralCandida albicans. PutativeC. albicans colony-forming units on selective bismuth sulfite glucose glycine yeast agar plates were identified with the API 20C system. The CHX minimum inhibitory concentrations (MICs) of oralC. albicans isolates obtained at all 8 sample weeks was determined with a microbroth dilution sensitivity assay. The CHX MIC range for yeast isolates selected randomly at all sample weeks was up to 2.5 to up to 20 μg/ml (mean MIC ≤8.5 μg/ml). The CHX MIC range for isolates at week 1 was ≤5 to ≤ 10 μg/ml (mean MIC ≤7.9 μg/ml) compared with ≤2.5 to ≤20 μg/ml at week 8 (mean MIC ≤8.8 μg/ml). Therefore the persistence of oralC. albicans in bone marrow transplant recipients using CHX rinses was due neither to low CHX susceptibilities nor to the development of resistance to the agent.

Original languageEnglish
Pages (from-to)291-295
Number of pages5
JournalOral Surgery, Oral Medicine, Oral Pathology
Volume72
Issue number3
DOIs
StatePublished - Sep 1991

Bibliographical note

Funding Information:
Supported by the Colleges of Dentistry and Medicine. BDepartment of Oral Health Science. bDepartments of Oral Health Practice and Pediatrics. CDepartment of Oral Health Practice. dDepartments of Pediatrics and Medicine.

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dentistry (all)

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