OralCandida albicans in bone marrow transplant patients given chlorhexidine rinses: Occurrence and susceptibilities to the agent

Jennifer M. Thurmond; Albert T. Brown; Robert E. Sims; Gerald A. Ferretti; Ted P. Raybould; Thomas T. Lillich; P. Jean Henslee

doi:10.1016/0030-4220(91)90217-Z

OralCandida albicans in bone marrow transplant patients given chlorhexidine rinses: Occurrence and susceptibilities to the agent

Jennifer M. Thurmond, Albert T. Brown, Robert E. Sims, Gerald A. Ferretti, Ted P. Raybould, Thomas T. Lillich, P. Jean Henslee

Oral Health Science

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

The tongue and buccal mucosa of 26 bone marrow transplant recipients given three 0.12% chlorhexidine digluconate (CHX) oral rinses daily for 8 weeks were sampled weekly for oralCandida albicans. PutativeC. albicans colony-forming units on selective bismuth sulfite glucose glycine yeast agar plates were identified with the API 20C system. The CHX minimum inhibitory concentrations (MICs) of oralC. albicans isolates obtained at all 8 sample weeks was determined with a microbroth dilution sensitivity assay. The CHX MIC range for yeast isolates selected randomly at all sample weeks was up to 2.5 to up to 20 μg/ml (mean MIC ≤8.5 μg/ml). The CHX MIC range for isolates at week 1 was ≤5 to ≤ 10 μg/ml (mean MIC ≤7.9 μg/ml) compared with ≤2.5 to ≤20 μg/ml at week 8 (mean MIC ≤8.8 μg/ml). Therefore the persistence of oralC. albicans in bone marrow transplant recipients using CHX rinses was due neither to low CHX susceptibilities nor to the development of resistance to the agent.

Original language	English
Pages (from-to)	291-295
Number of pages	5
Journal	Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume	72
Issue number	3
DOIs	https://doi.org/10.1016/0030-4220(91)90217-Z
State	Published - Sep 1991

Bibliographical note

Funding Information:
Supported by the Colleges of Dentistry and Medicine. BDepartment of Oral Health Science. bDepartments of Oral Health Practice and Pediatrics. CDepartment of Oral Health Practice. dDepartments of Pediatrics and Medicine.

Funding

Supported by the Colleges of Dentistry and Medicine. BDepartment of Oral Health Science. bDepartments of Oral Health Practice and Pediatrics. CDepartment of Oral Health Practice. dDepartments of Pediatrics and Medicine.

Funders	Funder number
Colleges of Dentistry and Medicine

ASJC Scopus subject areas

Pathology and Forensic Medicine
General Dentistry

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Thurmond, J. M., Brown, A. T., Sims, R. E., Ferretti, G. A., Raybould, T. P., Lillich, T. T., & Henslee, P. J. (1991). OralCandida albicans in bone marrow transplant patients given chlorhexidine rinses: Occurrence and susceptibilities to the agent. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 72(3), 291-295. https://doi.org/10.1016/0030-4220(91)90217-Z

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title = "OralCandida albicans in bone marrow transplant patients given chlorhexidine rinses: Occurrence and susceptibilities to the agent",

abstract = "The tongue and buccal mucosa of 26 bone marrow transplant recipients given three 0.12% chlorhexidine digluconate (CHX) oral rinses daily for 8 weeks were sampled weekly for oralCandida albicans. PutativeC. albicans colony-forming units on selective bismuth sulfite glucose glycine yeast agar plates were identified with the API 20C system. The CHX minimum inhibitory concentrations (MICs) of oralC. albicans isolates obtained at all 8 sample weeks was determined with a microbroth dilution sensitivity assay. The CHX MIC range for yeast isolates selected randomly at all sample weeks was up to 2.5 to up to 20 μg/ml (mean MIC ≤8.5 μg/ml). The CHX MIC range for isolates at week 1 was ≤5 to ≤ 10 μg/ml (mean MIC ≤7.9 μg/ml) compared with ≤2.5 to ≤20 μg/ml at week 8 (mean MIC ≤8.8 μg/ml). Therefore the persistence of oralC. albicans in bone marrow transplant recipients using CHX rinses was due neither to low CHX susceptibilities nor to the development of resistance to the agent.",

author = "Thurmond, {Jennifer M.} and Brown, {Albert T.} and Sims, {Robert E.} and Ferretti, {Gerald A.} and Raybould, {Ted P.} and Lillich, {Thomas T.} and Henslee, {P. Jean}",

note = "Funding Information: Supported by the Colleges of Dentistry and Medicine. BDepartment of Oral Health Science. bDepartments of Oral Health Practice and Pediatrics. CDepartment of Oral Health Practice. dDepartments of Pediatrics and Medicine.",

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doi = "10.1016/0030-4220(91)90217-Z",

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AU - Ferretti, Gerald A.

AU - Raybould, Ted P.

AU - Lillich, Thomas T.

AU - Henslee, P. Jean

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PY - 1991/9

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N2 - The tongue and buccal mucosa of 26 bone marrow transplant recipients given three 0.12% chlorhexidine digluconate (CHX) oral rinses daily for 8 weeks were sampled weekly for oralCandida albicans. PutativeC. albicans colony-forming units on selective bismuth sulfite glucose glycine yeast agar plates were identified with the API 20C system. The CHX minimum inhibitory concentrations (MICs) of oralC. albicans isolates obtained at all 8 sample weeks was determined with a microbroth dilution sensitivity assay. The CHX MIC range for yeast isolates selected randomly at all sample weeks was up to 2.5 to up to 20 μg/ml (mean MIC ≤8.5 μg/ml). The CHX MIC range for isolates at week 1 was ≤5 to ≤ 10 μg/ml (mean MIC ≤7.9 μg/ml) compared with ≤2.5 to ≤20 μg/ml at week 8 (mean MIC ≤8.8 μg/ml). Therefore the persistence of oralC. albicans in bone marrow transplant recipients using CHX rinses was due neither to low CHX susceptibilities nor to the development of resistance to the agent.

AB - The tongue and buccal mucosa of 26 bone marrow transplant recipients given three 0.12% chlorhexidine digluconate (CHX) oral rinses daily for 8 weeks were sampled weekly for oralCandida albicans. PutativeC. albicans colony-forming units on selective bismuth sulfite glucose glycine yeast agar plates were identified with the API 20C system. The CHX minimum inhibitory concentrations (MICs) of oralC. albicans isolates obtained at all 8 sample weeks was determined with a microbroth dilution sensitivity assay. The CHX MIC range for yeast isolates selected randomly at all sample weeks was up to 2.5 to up to 20 μg/ml (mean MIC ≤8.5 μg/ml). The CHX MIC range for isolates at week 1 was ≤5 to ≤ 10 μg/ml (mean MIC ≤7.9 μg/ml) compared with ≤2.5 to ≤20 μg/ml at week 8 (mean MIC ≤8.8 μg/ml). Therefore the persistence of oralC. albicans in bone marrow transplant recipients using CHX rinses was due neither to low CHX susceptibilities nor to the development of resistance to the agent.

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OralCandida albicans in bone marrow transplant patients given chlorhexidine rinses: Occurrence and susceptibilities to the agent

Abstract

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