Organ blood flow during arteriovenous carbon dioxide removal

Robert L. Brunston, Weike Tao, Akhil Bidani, Daniel L. Traber, Joseph B. Zwischenberger

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Animal models of arteriovenous carbon dioxide removal (AVCO2R) have achieved lung rest during treatment of severe respiratory failure, with total CO2 removal at arteriovenous shunt flow rates of 10% to 25% of cardiac output (CO). Previously, no statistically significant changes were reported in heart rate, cardiac output, mean arterial pressure, or pulmonary arterial pressure during prolonged (7 days) AVCO2R with shunt flows to 25% of CO. In this study, to determine the effect of various shunt levels on organ blood flow, colored microspheres were used in a conscious ovine model of AVCO2R. It was concluded that AVCO2R can achieve lung rest during respiratory failure at flow rates of 10-25% CO, with a resultant mild decrease in critical organ blood flow that appears well tolerated.

Original languageEnglish
Pages (from-to)M821-M824
JournalASAIO Journal
Issue number5
StatePublished - 1997

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering


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