Organ culture modeling of distraction osteogenesis

Marnie M. Saunders, J. Van Sickels, B. Heil, K. Gurley

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Bone cell mechanotransduction involves the process by which bone cells sense and coordinate their activity in response to mechanical loading. In vitro and in vivo models are commonly used but may overly simplify (in vitro) or complicate (in vivo) the response making the effects of the load difficult to discern or of questionable clinical relevance. The author previously proposed the use of an organ culture system for mechanotransduction studies. In contrast to previous organ culture research addressing accelerated resorption effects, the goal was to determine if a whole bone organ culture could remain viable in culture for a period of time sufficient to study the short-term response of physiologic loading-induced maintenance/osteogenesis. If successful, the organ culture system would provide more of a biomimetic environment simplifying the systemic response seen in vivo while increasing the biological relevance over in vitro systems. Here we continue with this work. That is, to be useful as a mechanotransduction model, the organ culture system needs to be able to correctly simulate relevant, clinical conditions. In the current paper, the applicability of an organ culture approach to simulate distraction osteogenesis is evaluated and initial effects on bone viability and mechanical performance are presented.

Original languageEnglish
Title of host publicationMechanics of Biological Systems and Materials - Proceedings of the 2011 Annual Conference on Experimental and Applied Mechanics
Number of pages7
StatePublished - 2011
Event2011 SEM Annual Conference on Experimental and Applied Mechanics - Uncasville, CT, United States
Duration: Jun 13 2011Jun 16 2011

Publication series

NameConference Proceedings of the Society for Experimental Mechanics Series
ISSN (Print)2191-5644
ISSN (Electronic)2191-5652


Conference2011 SEM Annual Conference on Experimental and Applied Mechanics
Country/TerritoryUnited States
CityUncasville, CT

ASJC Scopus subject areas

  • General Engineering
  • Computational Mechanics
  • Mechanical Engineering


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